Clock Antibody (YA4796)

Clock Antibody (YA4796) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Clock. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human.

Clock is a transcriptional activator that serves as a core component of the circadian clock, an internal time-keeping system that generates approximately 24-hour rhythms in gene expression, metabolism, and behavior. Derived from the Latin roots 'circa' (about) and 'diem' (day), it regulates diverse physiological functions including metabolism, sleep, blood pressure, and immune responses. The clock consists of a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain and peripheral clocks in tissues, both synchronized by environmental Zeitgebers ('time-givers'), primarily light for the SCN. The molecular mechanism involves a transcription-translation feedback loop (TTFL) where CLOCK-BMAL1 heterodimers (positive limb) activate E-box-containing genes, while PER/CRY proteins (negative limb) inhibit this activity. CLOCK also exhibits acetyltransferase activity, rhythmically modifying histones and nonhistone proteins (e.g., BMAL1) to regulate chromatin accessibility. Disrupted circadian rhythms contribute to diseases like cancer and metabolic disorders. By similarity: Drives blood pressure rhythms via transcriptional activation of ATP1B1.

O15516

Predicted band size: 95 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; ELISA: 1:10000

WB, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Clock expressed in E. Coli.