2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-PEG5-COOH

Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-PEG5-COOH

Thalidomide-PEG5-COOH Chemical Structure

CAS No. : 2688100-28-7

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Based on 1 publication(s) in Google Scholar

Thalidomide-PEG5-COOH Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-PEG5-COOH Related Antibodies
Molecular Weight

522.50

Formula

C24H30N2O11
CAS No.
Appearance

Oil

Color

Light yellow to brown

SMILES

O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(OCCOCCOCCOCCOCCC(O)=O)C=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9139 mL 9.5694 mL 19.1388 mL
5 mM 0.3828 mL 1.9139 mL 3.8278 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9139 mL 9.5694 mL 19.1388 mL 47.8469 mL
5 mM 0.3828 mL 1.9139 mL 3.8278 mL 9.5694 mL
10 mM 0.1914 mL 0.9569 mL 1.9139 mL 4.7847 mL
15 mM 0.1276 mL 0.6380 mL 1.2759 mL 3.1898 mL
20 mM 0.0957 mL 0.4785 mL 0.9569 mL 2.3923 mL
25 mM 0.0766 mL 0.3828 mL 0.7656 mL 1.9139 mL
30 mM 0.0638 mL 0.3190 mL 0.6380 mL 1.5949 mL
40 mM 0.0478 mL 0.2392 mL 0.4785 mL 1.1962 mL
50 mM 0.0383 mL 0.1914 mL 0.3828 mL 0.9569 mL
60 mM 0.0319 mL 0.1595 mL 0.3190 mL 0.7974 mL
80 mM 0.0239 mL 0.1196 mL 0.2392 mL 0.5981 mL
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Thalidomide-PEG5-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-PEG5-COOH2688100-28-7E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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