Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)

Cat. No.: HY-P990156 Purity: 95.00%: Data Sheet
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Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1 IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1⁺ cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE).

For research use only. We do not sell to patients.

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Mouse IgG2a kappa

Recommend Isotype Controls

Mouse IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

Thy1.1/CD90.1

In Vivo

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (200 μg, i.p., single dose on day 8 or once daily from day 64 or day 67) exhausts CD90.1⁺ cells in 10BiT/Foxp3eGFP mice with a house dust mite (HDM) induced allergic airway inflammation model^[1].
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (250 μg, i.p., single dose, 133 days after the injection of Tregs-IL2pa) can clear Tregs in male B6 Thy1.2 mice with a cell transplantation model^[2].
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (200 µg, i.p. once every other day, until symptoms of the disease appear) exhausts Thy1.1⁺ dendritic cells (DCs) in C57BL/6 mice with a MOG_35-55 (HY-P1240) induced experimental autoimmune encephalomyelitis (EAE) model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	10BiT/Foxp3eGFP mice (6-8 weeks) with HDM (20 μg) induced allergic airway inflammation model^[1]
Dosage:	200 μg
Administration:	Intraperitoneal injection (i.p.), single dose on day 8 for the acute model and once daily from day 64 or day 67 for the memory model
Result:	Exacerbated inflammation and increased eosinophils in the acute model. Did not affect inflammation or cytokine production in the memory model.

Animal Model:	9×10⁵ Tregs-IL2pa male B6 Thy1.2 mice (12-20 weeks)^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection (i.p.), single dose, 133 days after the injection of Tregs-IL2pa
Result:	Could effectively clear Tregs-IL2pa marked with Thy1.1 and the removal effect was long-lasting.

Animal Model:	MOG_35-55 (200 μg) induced C57BL/6 mice^[3]
Dosage:	200 µg
Administration:	Intraperitoneal injection (i.p.), once every other day, until symptoms of the disease appear
Result:	Significantly inhibited the development of EAE. Significantly reduced EAE score.

Gene ID

21838 [NCBI]

Accession

P01831

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Yadava K, et al. Natural Tr1-like cells do not confer long-term tolerogenic memory. Elife. 2019 Oct 11;8:e44821. [Content Brief]

[2]. Robert J, et al. Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models. Nat Commun. 2025 May 27;16(1):4891. [Content Brief]

[3]. Heink S, et al. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85. [Content Brief]

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)Transmembrane GlycoproteinThy1.1/CD90.1TregimmunologyEAEairway inflammationInhibitorinhibitorinhibit

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