Anti-Mouse CD205 Antibody (NLDC-145)

Cat. No.: HY-P990284: Data Sheet
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Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes.

For research use only. We do not sell to patients.

Anti-Mouse CD205 Antibody (NLDC-145) Chemical Structure

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Biological Activity
Purity & Documentation
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Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD205

In Vitro

Anti-Mouse CD205 Antibody (NLDC-145) (Ins2 cDNA in frame with the C terminus of the H chain of an NLDC-145) binds to insulin polyclonal Ab^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD205 Antibody (NLDC-145) (1 μg, i.p., at days -2 and -1) reduces inflammation in conjugation of the HA_110-120 peptide in in colitis VILLIN-HA transgenic mice transferred with CD4⁺Foxp3⁻ T cells^[1].
Anti-Mouse CD205 Antibody (NLDC-145) (complex composed of the extracellular domain of HER2/neu and the NLDC-145 antibody) (50 μg, intramuscular injection, at days-21 and -7) inhibits tumor growth and increases survival rate in D2F2/E2 tumor mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	D2F2/E2 tumor mice models^[2]
Dosage:	50 μg
Administration:	Intramuscularly injection, at days -21 and -7
Result:	Showed slow tumor growth. Increased survival rate. Showed higher percentage of CD4⁺ and CD8⁺ T cells producing IFN-γ and TNF-α.

Gene ID

17076 [NCBI]

Accession

Q60767

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD205 Antibody (NLDC-145)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Wadwa M, et al. Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice. Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. [Content Brief]

[2]. Cao J, et al. DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. BMC Immunol. 2013 Aug 14;14:39. [Content Brief]

[3]. Schloss J, et al. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons. 2019 Jun 26;3(6):236-253. [Content Brief]

Anti-Mouse CD205 Antibody (NLDC-145) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD205 Antibody (NLDC-145)C-type Lectin-like Receptors (CTLRs)CD205DEC-205ColitisD2F2/E2DiabetesVILLIN-HAInhibitorinhibitorinhibit

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