Ethyl phenylglyoxylate-d₅  (Synonyms: Ethyl benzoylformate-d₅; Phenylglyoxylic acid ethyl ester-d₅)

Ethyl phenylglyoxylate-d₅ (Ethyl benzoylformate-d₅; Phenylglyoxylic acid ethyl ester-d₅) is the deuterium labeled Ethyl phenylglyoxylate (HY-W016618). Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions^[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

183.22

C₁₀H₅D₅O₃

1025892-26-5

1603-79-8

[2H]C1=C([2H])C([2H])=C(C(C(OCC)=O)=O)C([2H])=C1[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shengkui Hu, et al. Photochemically Active Polymers Containing Pendant Ethyl Phenylglyoxylate. Macromolecules 1998, 31, 2, 322-327.

  [2]. Hu S, et al. Photoreduction of ethyl phenylglyoxylate. Journal of Photochemistry and Photobiology A: Chemistry, 1998, 114(2): 103-108.

  [3]. Berndt M C, et al. Ethyl phenylglyoxylate, a simultaneous inhibitor and substrate of chicken liver carboxylesterase (EC 3.1. 1.1). Enzyme-catalyzed fragmentation of (E)-benzil monoxime O-2, 4-dinitrophenyl ether. Journal of the American Chemical Society, 1977, 99(25): 8334-8335.