2. Apoptosis
  3. Bcl-2 Family
  4. XZ338

XZ338 is a highly selective degrader targeting BCL-XL. XZ338 does not degrade BCL-2. XZ338 inhibits MOLT-4 cells with a IC50 value of 3.7 nM. XZ338 has anti-proliferative activity. XZ338 can be used for anti-cancer study. (Target protein ligand: HY-19741; E3 ligase: HY-112078; linker: HY-172799; E3+liner: HY-172800).

For research use only. We do not sell to patients.

XZ338 Chemical Structure

XZ338 Chemical Structure

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XZ338 Related Antibodies

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Description

XZ338 is a highly selective degrader targeting BCL-XL. XZ338 does not degrade BCL-2. XZ338 inhibits MOLT-4 cells with a IC50 value of 3.7 nM. XZ338 has anti-proliferative activity. XZ338 can be used for anti-cancer study. (Target protein ligand: HY-19741; E3 ligase: HY-112078; linker: HY-172799; E3+liner: HY-172800)[1].

Molecular Weight

1290.66

Formula

C69H83N11O8S3
SMILES

O=C(NC1=NC2=CC=CC=C2S1)C3=CC=CC4=C3CN(C5=CC=C(C6=C(C)N(CC7(C[C@H]8C9)C[C@H]9C[C@H](C8)C7)N=C6)C(C(NS(CCCCCCCC(N[C@@H](C(C)(C)C)C(N%10[C@H](C(N[C@@H](C)C%11=CC=C(C%12=C(C)N=CS%12)C=C%11)=O)C[C@@H](O)C%10)=O)=O)(=O)=O)=O)=N5)CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XZ338 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XZ338XZ 338XZ-338Bcl-2 FamilyMOLT-4 cellscancerInhibitorinhibitorinhibit

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