JQ-1 carboxylic acid-PEG3-C2-NH2

Cat. No.: HY-169150 Purity: 99.39%: Data Sheet
COA

SDS
Handling Instructions
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JQ-1 carboxylic acid-PEG3-C2-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT.

For research use only. We do not sell to patients.

JQ-1 carboxylic acid-PEG3-C2-NH2 Chemical Structure

CAS No. : 2098790-24-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of JQ-1 carboxylic acid-PEG3-C2-NH2:

JQ-1 carboxylic acid-PEG3-C2-NH2 hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

JQ-1 carboxylic acid-PEG3-C2-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT^[1].

Molecular Weight

575.12

Formula

C₂₇H₃₅ClN₆O₄S

CAS No.

2098790-24-8

Appearance

Oil

Color

Off-white to light brown

SMILES

NCCOCCOCCOCCNC(C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C(C)=NN=C14)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (173.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7388 mL	8.6938 mL	17.3877 mL
5 mM	0.3478 mL	1.7388 mL	3.4775 mL
10 mM	0.1739 mL	0.8694 mL	1.7388 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.39%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (248 KB) HNMR (136 KB) RP-HPLC (284 KB) NP-HPLC (126 KB) LCMS (385 KB)

Handling Instructions (2659 KB)

References

[1]. Tao Y, et, al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144(40):18688-18699. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7388 mL	8.6938 mL	17.3877 mL	43.4692 mL
	5 mM	0.3478 mL	1.7388 mL	3.4775 mL	8.6938 mL
	10 mM	0.1739 mL	0.8694 mL	1.7388 mL	4.3469 mL
	15 mM	0.1159 mL	0.5796 mL	1.1592 mL	2.8979 mL
	20 mM	0.0869 mL	0.4347 mL	0.8694 mL	2.1735 mL
	25 mM	0.0696 mL	0.3478 mL	0.6955 mL	1.7388 mL
	30 mM	0.0580 mL	0.2898 mL	0.5796 mL	1.4490 mL
	40 mM	0.0435 mL	0.2173 mL	0.4347 mL	1.0867 mL
	50 mM	0.0348 mL	0.1739 mL	0.3478 mL	0.8694 mL
	60 mM	0.0290 mL	0.1449 mL	0.2898 mL	0.7245 mL
	80 mM	0.0217 mL	0.1087 mL	0.2173 mL	0.5434 mL
	100 mM	0.0174 mL	0.0869 mL	0.1739 mL	0.4347 mL