2. Others Membrane Transporter/Ion Channel Apoptosis
  3. Isotope-Labeled Compounds Proton Pump Apoptosis
  4. Rabeprazole-d4 sodium

Rabeprazole-d4 sodium  (Synonyms: LY307640-d4 sodium)

Cat. No.: HY-B0656AS Purity: 98.61%
SDS
COA
Handling Instructions Technical Support

Rabeprazole-d4 (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

For research use only. We do not sell to patients.

Rabeprazole-d<sub>4</sub> sodium Chemical Structure

Rabeprazole-d4 sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Rabeprazole-d4 sodium:

Rabeprazole-d4 sodium Related Antibodies

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Description

Rabeprazole-d4 (sodium) is the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rabeprazole-d4 sodium Related Antibodies
Molecular Weight

385.45

Formula

C18H16D4N3NaO3S
Unlabeled CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C1=NC2=C([2H])C([2H])=C([2H])C([2H])=C2N1[Na])CC3=NC=CC(OCCCOC)=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (259.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5944 mL 12.9719 mL 25.9437 mL
5 mM 0.5189 mL 2.5944 mL 5.1887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.61%

SDS (393 KB)

COA (247 KB) HNMR (114 KB) RP-HPLC (167 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5944 mL 12.9719 mL 25.9437 mL 64.8593 mL
5 mM 0.5189 mL 2.5944 mL 5.1887 mL 12.9719 mL
10 mM 0.2594 mL 1.2972 mL 2.5944 mL 6.4859 mL
15 mM 0.1730 mL 0.8648 mL 1.7296 mL 4.3240 mL
20 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
25 mM 0.1038 mL 0.5189 mL 1.0377 mL 2.5944 mL
30 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1620 mL
40 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
50 mM 0.0519 mL 0.2594 mL 0.5189 mL 1.2972 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0810 mL
80 mM 0.0324 mL 0.1621 mL 0.3243 mL 0.8107 mL
100 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.6486 mL
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Rabeprazole-d4 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rabeprazole-d4LY307640-d4Isotope-Labeled CompoundsProton PumpApoptosisInhibitorinhibitorinhibit

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