CD97 Protein, Human (HEK293, hFc)

CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, hFc) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-hFc labeled tag.

CD97, a receptor with potential involvement in both adhesion and signaling processes during early leukocyte activation, plays a crucial role in facilitating leukocyte migration. This receptor forms a heterodimer, comprising a large extracellular alpha subunit non-covalently linked to a seven-transmembrane beta subunit. CD97 interacts with complement decay-accelerating factor (DAF) and the largest isoform (isoform 1) specifically engages with chondroitin sulfate, highlighting its diverse interactions in cellular processes.

Measured by its binding ability in a functional ELISA. Immobilized human CD55 at 2 μg/mL (100 μl/well) can bind human CD97 with a linear range of 1.28-32 ng/mL.

Human

HEK293

C-hFc

P48960-2/NP_001775.2 (Q21-Q398)

976  [NCBI]

Partial

MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQ

100-110 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.