PDHA1 Protein, Human (His, Myc)

The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (His, Myc) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with C-Myc and N-10*His labeled tag.

PDHA1 protein, a crucial constituent of the pyruvate dehydrogenase complex, plays a pivotal role in orchestrating the comprehensive conversion of pyruvate into acetyl-CoA and CO2. This enzymatic process establishes a fundamental link between the glycolytic pathway and the tricarboxylic acid (TCA) cycle, facilitating the seamless integration of metabolic pathways. PDHA1's catalytic function is essential for the efficient transformation of pyruvate, ensuring the flow of carbon substrates into the TCA cycle for subsequent energy generation and metabolic homeostasis within the cell.

Human

E. coli

C-Myc;N-10*His

P08559 (A31-S390)

5160

Partial

ANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.