2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C-IN-70

KRAS G12C-IN-70 is a selective KRAS G12C mutant inhibitor. KRAS G12C-IN-70 blocks KRAS G12C-mediated downstream signaling pathways (e.g., RAF-MEK-ERK) and inhibits tumor cell proliferation. KRAS G12C-IN-70 is promising for research of KRAS G12C mutation-related tumors (such as non-small cell lung cancer, colorectal cancer).

For research use only. We do not sell to patients.

KRAS G12C-IN-70 Chemical Structure

KRAS G12C-IN-70 Chemical Structure

CAS No. : 2923865-76-1

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KRAS G12C-IN-70 Related Antibodies

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Description

KRAS G12C-IN-70 is a selective KRAS G12C mutant inhibitor. KRAS G12C-IN-70 blocks KRAS G12C-mediated downstream signaling pathways (e.g., RAF-MEK-ERK) and inhibits tumor cell proliferation. KRAS G12C-IN-70 is promising for research of KRAS G12C mutation-related tumors (such as non-small cell lung cancer, colorectal cancer)[1].

IC50 & Target

KRAS(G12C)

 

Molecular Weight

552.98

Formula

C26H19ClF2N6O2S
CAS No.
SMILES

C=CC(N1CCN2C(C3=C(C4=C(C5=C6C(SC(N)=C6C#N)=C(F)C=C5)C(F)=C3)N(N=C4Cl)CC[C@@H]2C1)=O)=O
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Purity & Documentation
References
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KRAS G12C-IN-70 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C-IN-702923865-76-1RasKRAS G12C mutantRAF-MEK-ERKKRAS G12C mutation-related tumorsInhibitorinhibitorinhibit

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