2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. OUL312

OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15(IC50 = 1500 nM). OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer.

For research use only. We do not sell to patients.

OUL312

OUL312 Chemical Structure

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OUL312 Related Antibodies

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View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

OUL312 is a potent PARP10 inhibitor (IC50 = 20 nM), showing more than 75-fold greater selectivity for PARP15(IC50 = 1500 nM). OUL312 is also at least 18-fold higher than all other human enzymes in the family. OUL312 has a good ADME profile, is able to enter cells, is not toxic, and effectively rescues human cells from PARP10-induced apoptosis at sub-micromolar concentrations. OUL312 can be used for the study of cervical cancer[1].

IC50 & Target

PARP10

 

In Vitro

OUL312 (Compound 15) (0.05-10 μM, 10-12 days) shows no significant cytotoxicity in HeLa Flp-In TRex cells and could rescue Doxycycline (HY-N0565)-induced HeLa Flp-In TRex cells in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OUL312 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa Flp-In T-Rex cells
Concentration: 10 μM
Incubation Time: 10-12 days
Result: Showed no significant cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: Doxycycline-induced HeLa Flp-In T-Rex cells
Concentration: 0.05 μM, 0.1 μM, 0.5 μM, 1 μM, 10 μM
Incubation Time: 10-12 days
Result: Rescued cells in a concentration-dependent manner with apparent EC50 below 1 μM.
Molecular Weight

300.28

Formula

C16H13FN2O3
SMILES

O=C1NNC(C2=C1C=CC(OCCC3=CC=CC=C3F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OUL312 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OUL312OUL 312OUL-312PARPApoptosispoly ADP ribose polymerase 2,3-Dihydrophthalazine-1,4-dioneADP-RibosylationInhibitorPARP10inhibitorinhibit

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