E6446 dihydrochloride (Standard)

Cat. No.: HY-12756AR Purity: ≥98%: Handling Instructions
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E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).

For research use only. We do not sell to patients.

E6446 dihydrochloride (Standard) Chemical Structure

CAS No. : 1345675-25-3

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Description	E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).
Molecular Weight	522.51
Formula	C₂₇H₃₇Cl₂N₃O₃
CAS No.	1345675-25-3
SMILES	[H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Handling Instructions (2659 KB)

E6446 dihydrochloride (Standard) Related Classifications

Metabolic Disease Inflammation/Immunology

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6446 dihydrochloride (Standard)1345675-25-3Toll-like Receptor (TLR)Stearoyl-CoA Desaturase (SCD)high-fat dietnon-alcoholic fatty liver diseaseNAFLDadipogenic differentiationhepatic lipogenesisInhibitorinhibitorinhibit

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E6446 dihydrochloride (Standard)

Product Information

Purity & Documentation

Customer Review

E6446 dihydrochloride (Standard) Related Classifications

Molarity Calculator

Dilution Calculator