2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)
  4. E6446 dihydrochloride (Standard)

E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).

For research use only. We do not sell to patients.

E6446 dihydrochloride (Standard)

E6446 dihydrochloride (Standard) Chemical Structure

CAS No. : 1345675-25-3

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

522.51

Formula

C27H37Cl2N3O3
CAS No.
SMILES

[H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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E6446 dihydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6446 dihydrochloride (Standard)1345675-25-3Toll-like Receptor (TLR)Stearoyl-CoA Desaturase (SCD)high-fat dietnon-alcoholic fatty liver diseaseNAFLDadipogenic differentiationhepatic lipogenesisInhibitorinhibitorinhibit

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E6446 dihydrochloride (Standard)
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