2. Others Epigenetics Apoptosis
  3. Reference Standards Histone Methyltransferase Apoptosis
  4. Tazemetostat (Standard)

Tazemetostat (Standard)  (Synonyms: EPZ-6438 (Standard); E-7438 (Standard))

Cat. No.: HY-13803R Purity: 99.72%
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Tazemetostat (Standard) is the analytical standard of Tazemetostat. This product is intended for research and analytical applications. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

For research use only. We do not sell to patients.

Tazemetostat (Standard)

Tazemetostat (Standard) Chemical Structure

CAS No. : 1403254-99-8

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

572.74

Formula

C34H44N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Tazemetostat (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tazemetostat (Standard)1403254-99-8EPZ-6438 (Standard)E-7438 (Standard)Reference StandardsHistone MethyltransferaseApoptosisEZH2PRC2EZH1epigeneticcancerInhibitorinhibitorinhibit

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