Bcl-10 Antibody (YA3579)

Bcl-10 Antibody (YA3579) is a mouse-derived and non-conjugated IgG1 antibody, targeting to BCL-10. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse.

Bcl10 plays a pivotal role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins (e.g., CARD9, CARD11, and CARD14) to activate NF-kappa-B and MAP kinase p38 (MAPK11/12/13/14) pathways, thereby stimulating pro-inflammatory cytokine and chemokine gene expression. It forms polymers via CARD-CARD interactions with activated CARD proteins, recruits MALT1, and assembles into the CBM complex. Additionally, Bcl10 promotes apoptosis, pro-caspase-9 maturation, and NF-kappa-B activation via NIK and IKK. By similar mechanisms: it is activated by CARD9 downstream of C-type lectin receptors (essential for antifungal immunity) and by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR).

O95999

Predicted band size: 26 kDa; Observed band size: 26 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in ascitic fluid containing 0.03% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human BCL-10 expressed in E. Coli.