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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. HIF-2 alpha Antibody (YA3517)

HIF-2 alpha Antibody (YA3517)

Cat. No.: HY-P81153
COA
SDS
User Guide for Antibodies Technical Support

HIF-2 alpha Antibody (YA3517) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF-2 alpha.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

HIF-2 alpha Antibody (YA3517) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF-2 alpha.
Background

HIF 2 alpha is a transcription factor involved in the induction of oxygen-regulated genes. It heterodimerizes with ARNT, and the heterodimer binds to the core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (by similar). It regulates vascular endothelial growth factor (VEGF) expression and appears to play a role in blood vessel and lung tubular system development, as well as potentially in the formation of the endothelium associated with the blood-brain barrier. HIF 2 alpha is a potent activator of Tie-2 tyrosine kinase expression, requiring recruitment of transcriptional coactivators such as CREBBP and likely EP300 for activation. Interaction with the redox regulatory protein APEX1 seems to activate CTAD (by similar).
Gene ID
SwissProt ID
Synonyms
Basic helix loop helix PAS protein MOP2; Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; Endothelial PAS domain containing protein 1; Endothelial pas domain protein 1; Endothelial PAS domain-containing protein 1; EPAS 1; EPAS-1; EPAS1; EPAS1_HUMAN; HIF 1 alpha like factor; HIF-1-alpha-like factor; HIF-2-alpha; HIF2-alpha; HIF2A; HLF; Hypoxia inducible factor 2 alpha; Hypoxia inducible factor 2 alpha subunit; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; Member of pas superfamily 2; MOP 2; MOP2; PAS domain-containing protein 2; PASD2.
Molecular Weight

Predicted band size: 96kDa;Observed band size: 110 kDa
Purity

affinity purified
Subcellular Location

Nucleus (Potential).
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Monoclonal, Recombinant
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:2,000;IHC-P:1:50-1:1,000;FC: 1:50-1:100;
Application

WB, IHC-P, FC
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide within Human HIF-2 alpha aa 61-110 / 870.
Database

Entrez Gene: 2034 Human ;

SwissProt: Q99814 Human ;

OMIM: 611783 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

HIF-2 alpha Antibody (YA3517) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HIF-2 alpha Antibody (YA3517)
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