Aryl Hydrocarbon Receptor Antibody (YA2162)

Aryl Hydrocarbon Receptor Antibody (YA2162) is a non-conjugated IgG antibody, targeting Aryl Hydrocarbon Receptor, with a predicted molecular weight of 96 kDa (observed band size: 100 kDa). Aryl Hydrocarbon Receptor Antibody (YA2162) can be used for WB experiment in human background.

The Aryl Hydrocarbon Receptor (AHR) is a ligand-activated transcription factor that enables cellular adaptation to environmental, dietary, microbial, and metabolic cues, playing critical roles in development, immunity, and cancer. Upon ligand binding, AHR translocates to the nucleus, heterodimerizes with ARNT, and induces gene expression by binding to xenobiotic response elements (XRE). It regulates diverse processes, including angiogenesis, hematopoiesis, drug/lipid metabolism, cell motility, and immune modulation. Xenobiotics (e.g., halogenated aromatic hydrocarbons) act as ligands, triggering phase I/II metabolizing enzyme gene expression (e.g., CYP1A1). Natural ligands from plants, microbiota, and endogenous metabolism (e.g., tryptophan derivatives) also potently activate AHR. Notably, AHR suppresses anti-tumor immunity—tryptophan catabolites (indoles, kynurenic acid) promote cancer cell motility and dampen adaptive immunity via AHR activation. Additionally, AHR inhibits the circadian gene PER1 by repressing CLOCK-BMAL1-mediated transcription. by similar: The AHR:ARNT heterodimer binds the core DNA sequence 5'-TGCGTG-3' within dioxin response elements (DRE) to activate target gene transcription.

P35869

Predicted band size: 96 kDa; Observed band size: 100 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human Aryl hydrocarbon Receptor