2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. VH 032 amide-alkylC5-azide

VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand.

For research use only. We do not sell to patients.

VH 032 amide-alkylC5-azide Chemical Structure

VH 032 amide-alkylC5-azide Chemical Structure

CAS No. : 2821804-11-7

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VH 032 amide-alkylC5-azide Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand[1].

Molecular Weight

569.72

Formula

C28H39N7O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[N-]=[N+]=NCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (109.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7552 mL 8.7762 mL 17.5525 mL
5 mM 0.3510 mL 1.7552 mL 3.5105 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7552 mL 8.7762 mL 17.5525 mL 43.8812 mL
5 mM 0.3510 mL 1.7552 mL 3.5105 mL 8.7762 mL
10 mM 0.1755 mL 0.8776 mL 1.7552 mL 4.3881 mL
15 mM 0.1170 mL 0.5851 mL 1.1702 mL 2.9254 mL
20 mM 0.0878 mL 0.4388 mL 0.8776 mL 2.1941 mL
25 mM 0.0702 mL 0.3510 mL 0.7021 mL 1.7552 mL
30 mM 0.0585 mL 0.2925 mL 0.5851 mL 1.4627 mL
40 mM 0.0439 mL 0.2194 mL 0.4388 mL 1.0970 mL
50 mM 0.0351 mL 0.1755 mL 0.3510 mL 0.8776 mL
60 mM 0.0293 mL 0.1463 mL 0.2925 mL 0.7314 mL
80 mM 0.0219 mL 0.1097 mL 0.2194 mL 0.5485 mL
100 mM 0.0176 mL 0.0878 mL 0.1755 mL 0.4388 mL
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VH 032 amide-alkylC5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 032 amide-alkylC5-azide2821804-11-7E3 Ligase Ligand-Linker ConjugatesVHLPROTACE3Inhibitorinhibitorinhibit

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