CLEC4E Protein, Rhesus Macaque (HEK293, Fc)

CLEC4E Protein is a calcium-dependent lectin displaying mannose-binding specificity, and induces the formation of Birbeck granules (BGs). CLEC4E Protein is a potent regulator of membrane superimposition and zippering, and binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC4E protein, expressed by HEK293 , with N-hFc labeled tag.

CLEC4E Protein facilitates uptake of antigens and is involved in the routing or processing of antigen for presentation to T cells. C-type lectin domain family 4 member E is a major receptor on primary langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. C-type lectin domain family 4 member E protects against human immunodeficiency virus-1 (HIV-1) infection^[1][2][3][4].

Measured by its binding ability in a functional ELISA. Immobilized Trehalose 6, 6'-Dimycolate at 1 μg/mL(100 μL/well) can bind Rhesus Macaque CLEC4E. The ED₅₀ for this effect is 0.2905 μg/mL.

• 
  Measured by its binding ability in a functional ELISA. Immobilized Trehalose 6, 6'-Dimycolate at 1 μg/mL(100 μL/well) can bind Rhesus Macaque CLEC4E. The ED₅₀ for this effect is 0.2905 μg/mL.

Rhesus Macaque

HEK293

N-hFc

XP_001118423.1 (R41-I219)

722250  [NCBI]

Partial

Approximately 49.1 kDa.

Greater than 85% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.