(E)-Naringenin chalcone

Cat. No.: HY-N3007A Purity: 98.87%: Data Sheet
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(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell.

For research use only. We do not sell to patients.

(E)-Naringenin chalcone Chemical Structure

CAS No. : 25515-46-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of (E)-Naringenin chalcone:

Naringenin chalcone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	> 10 μM Compound: 2b	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26690274]
MDA-MB-231	IC₅₀	> 10 μM Compound: 2b	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26690274]

In Vitro

(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC₅₀ value of 68 μg/mL^[1].
(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production^[2].
(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells^[2].
(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:	3T3-L1 adipocytes
Concentration:	25-100 μM
Incubation Time:	8 days
Result:	Increased adiponectin mRNA levels up to 8.0-fold in a dose-dependent manner.

Western Blot Analysis^[4]

Cell Line:	RAW 264 macrophages
Concentration:	0,25, 50, 100, 200 μM
Incubation Time:	24 h
Result:	Suppressed the degradation of IκB-α.

In Vivo

(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice^[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse type I allergic model^[1]
Dosage:	0.8 mg/kg
Administration:	Oral administration
Result:	Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.

Animal Model:	Allergic airway inflammation induced in mice^[3]
Dosage:	0.8 mg/kg
Administration:	Oral administration, daily
Result:	Decreased cell numbers of the infiltrating leukocyte and eosinophils. Decreased Muc5ac and gob-5 expression in the lungs.

Molecular Weight

272.26

Formula

C₁₅H₁₂O₅

CAS No.

25515-46-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C=C1)=CC=C1/C=C/C(C2=C(C=C(O)C=C2O)O)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (183.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6730 mL	18.3648 mL	36.7296 mL
5 mM	0.7346 mL	3.6730 mL	7.3459 mL
10 mM	0.3673 mL	1.8365 mL	3.6730 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.87%

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Data Sheet (274 KB) SDS (393 KB)

COA (246 KB) HNMR (255 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Taichi Yamamoto, et al. Anti-allergic activity of naringenin chalcone from a tomato skin extract. Biosci Biotechnol Biochem. 2004 Aug;68(8):1706-11. [Content Brief]

[2]. Taro Horiba, et al. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Mol Cell Endocrinol. 2010 Jul 29;323(2):208-14. [Content Brief]

[3]. Chiaki Iwamura, et al. Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol Int. 2010 Mar;59(1):67-73. [Content Brief]

[4]. Shizuka Hirai, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007 Sep 29;81(16):1272-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6730 mL	18.3648 mL	36.7296 mL	91.8240 mL
	5 mM	0.7346 mL	3.6730 mL	7.3459 mL	18.3648 mL
	10 mM	0.3673 mL	1.8365 mL	3.6730 mL	9.1824 mL
	15 mM	0.2449 mL	1.2243 mL	2.4486 mL	6.1216 mL
	20 mM	0.1836 mL	0.9182 mL	1.8365 mL	4.5912 mL
	25 mM	0.1469 mL	0.7346 mL	1.4692 mL	3.6730 mL
	30 mM	0.1224 mL	0.6122 mL	1.2243 mL	3.0608 mL
	40 mM	0.0918 mL	0.4591 mL	0.9182 mL	2.2956 mL
	50 mM	0.0735 mL	0.3673 mL	0.7346 mL	1.8365 mL
	60 mM	0.0612 mL	0.3061 mL	0.6122 mL	1.5304 mL
	80 mM	0.0459 mL	0.2296 mL	0.4591 mL	1.1478 mL
	100 mM	0.0367 mL	0.1836 mL	0.3673 mL	0.9182 mL