2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BET Degrader-13

PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC50 of 1.4 μM. Pink: BET ligand (HY-13030); Blue: E3 ligase ligand (HY-W1125585); Black: linker

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PROTAC BET Degrader-13

PROTAC BET Degrader-13 Chemical Structure

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PROTAC BET Degrader-13 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC50 of 1.4 μM[1]. Pink: BET ligand (HY-13030); Blue: E3 ligase ligand (HY-W1125585); Black: linker

Molecular Weight

908.51

Formula

C47H54ClN9O6S
SMILES

O=C(C[C@H]1N=C(C2=C(N3C(C)=NN=C13)SC=C2C)C4=CC=C(C=C4)Cl)NCCOCCOCCOCc5cc(N6C(C7=CC=CC=C7N=C6CN8CCNC[C@@H]8C)=O)c(OCC)cc5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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PROTAC BET Degrader-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BET Degrader-13PROTAC BET Degrader13PROTAC BET Degrader 13PROTACsEpigenetic Reader DomainPROTACDegradationBETTRIM21TRIMTACPML-eGFP-BRD4OCI-AML-3 cellsJURKAT cellsA549 cellsInhibitorinhibitorinhibit

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