2. Cell Cycle/DNA Damage Epigenetics PROTAC
  3. HDAC PROTACs
  4. JPS036

JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells.

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JPS036

JPS036 Chemical Structure

CAS No. : 2669785-85-5

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Based on 1 publication(s) in Google Scholar

JPS036 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Molecular Weight

940.18

Formula

C51H66FN7O7S
CAS No.
SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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References
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JPS036 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JPS0362669785-85-5JPS 036JPS-036HDACPROTACsHistone deacetylasesPROTACapoptosisInhibitorinhibitorinhibit

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