2. Apoptosis
  3. c-Myc
  4. VPC-70619

VPC-70619 is a potent N-Myc inhibitor. VPC-70619 blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box and exhibits potent inhibitory activity against N-Myc-dependent cell lines. VPC-70619 can partially reverse paclitaxel (HY-B0015) resistance in cells by reducing MYCN expression. VPC-70619 can be used for cancer research (e.g., neuroblastoma and thyroid cancer).

For research use only. We do not sell to patients.

VPC-70619

VPC-70619 Chemical Structure

CAS No. : 2361742-30-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 2 publication(s) in Google Scholar

VPC-70619 Related Antibodies

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Description

VPC-70619 is a potent N-Myc inhibitor. VPC-70619 blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box and exhibits potent inhibitory activity against N-Myc-dependent cell lines. VPC-70619 can partially reverse paclitaxel (HY-B0015) resistance in cells by reducing MYCN expression. VPC-70619 can be used for cancer research (e.g., neuroblastoma and thyroid cancer)[1][2].

In Vitro

VPC-70619 (10 μM) exhibits an inhibition rate of 99.4% in IMR32 cells, while only 14.1% in HO15.19 cells[1].
VPC-70619 (1-10 μM) is shown to be highly stable with a T1/2 of 2310 min in In liver microsomes[1].
VPC-70619 upregulates the mRNA levels of MYCN, MDM2, and CRABP2, and downregulates TGM2 and INHBA, confirming its specific regulatory effect on the MYCN signaling pathway in SW1736-PTX and 8505C-PTX cells[2].
VPC-70619 (0.5-30 μM, 0-72 h) inhibits the proliferation, migration and aggressiveness of SW1736-PTX and 8505C-PTX cells, and the effect is enhanced when combined with Paclitaxel[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-70619 Related Antibodies
Parmacokinetics[1]
Species Dose Route Indicator value
Mice 10 mg/kg i.p. Cmax 29500 ng/mL
Mice 10 mg/kg p.o. Cmax 24000 ng/mL
Mice 10 mg/kg i.p. Tmax 60 min
Mice 10 mg/kg p.o. Tmax 480 min
Mice 10 mg/kg i.p. T1/2 330 min
Mice 10 mg/kg p.o. T1/2 427 min
Molecular Weight

364.71

Formula

C16H8ClF3N4O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC(C(F)(F)F)=C(C=C1)NNC(C2=CC=C(C(Cl)=C2)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (274.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7419 mL 13.7095 mL 27.4190 mL
5 mM 0.5484 mL 2.7419 mL 5.4838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7419 mL 13.7095 mL 27.4190 mL 68.5476 mL
5 mM 0.5484 mL 2.7419 mL 5.4838 mL 13.7095 mL
10 mM 0.2742 mL 1.3710 mL 2.7419 mL 6.8548 mL
15 mM 0.1828 mL 0.9140 mL 1.8279 mL 4.5698 mL
20 mM 0.1371 mL 0.6855 mL 1.3710 mL 3.4274 mL
25 mM 0.1097 mL 0.5484 mL 1.0968 mL 2.7419 mL
30 mM 0.0914 mL 0.4570 mL 0.9140 mL 2.2849 mL
40 mM 0.0685 mL 0.3427 mL 0.6855 mL 1.7137 mL
50 mM 0.0548 mL 0.2742 mL 0.5484 mL 1.3710 mL
60 mM 0.0457 mL 0.2285 mL 0.4570 mL 1.1425 mL
80 mM 0.0343 mL 0.1714 mL 0.3427 mL 0.8568 mL
100 mM 0.0274 mL 0.1371 mL 0.2742 mL 0.6855 mL
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VPC-70619 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-706192361742-30-3VPC70619VPC 70619c-MycMycDNABioavailabilityIMR32NCI-H660 cellsHO15.19 cellsThyroid cancerPaclitaxelDrug resistanceBromodomainInhibitorinhibitorinhibit

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