2. Membrane Transporter/Ion Channel
  3. GLUT
  4. Rapaglutin E

Rapaglutin E (RgE) is a glucose transporter (GLUT) inhibitor. Rapaglutin E exhibits dose-dependent inhibition of [3H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC, with IC50 values 8.9 nM, 3.1 nM, 35.5 nM, 74.2 nM. Rapaglutin E inhibits cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells.

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Rapaglutin E Chemical Structure

Rapaglutin E Chemical Structure

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Rapaglutin E Related Antibodies

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Description

Rapaglutin E (RgE) is a glucose transporter (GLUT) inhibitor. Rapaglutin E exhibits dose-dependent inhibition of [3H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC, with IC50 values 8.9 nM, 3.1 nM, 35.5 nM, 74.2 nM. Rapaglutin E inhibits cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells[1].

Molecular Weight

1217.45

Formula

C67H88N6O15
SMILES

CN([C@@H](CCCC)C(N[C@H](C(N1C)=O)CC2=CC3=C(C=C2)C=CC=C3)=O)C(COC4=CC([C@H](OC([C@@H]5CCCCN5C(C(C(C)(C)COC(/C=C/CCN(C)C(CNC([C@@H]1COC(C)(C)C)=O)=O)=O)=O)=O)=O)CCC6=CC(OC)=C(OC)C=C6)=CC=C4)=O
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Rapaglutin E Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rapaglutin ERgEGLUTGlucose transporterglucose transporter (GLUT)[3H]-2DG uptakeA549Jurkat TPANC10.05RBCInhibitorinhibitorinhibit

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