2. Membrane Transporter/Ion Channel
  3. Calmodulin
  4. E6 Berbamine

E6 Berbamine  (Synonyms: Berbamine p-nitrobenzoate)

Cat. No.: HY-120997
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E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells.

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E6 Berbamine

E6 Berbamine Chemical Structure

CAS No. : 114784-59-7

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E6 Berbamine Related Antibodies

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Description

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
2.13 μM
Compound: 3n
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
[PMID: 19285759]
Molecular Weight

757.83

Formula

C44H43N3O9
CAS No.
SMILES

COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E6 Berbamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6 Berbamine114784-59-7Berbamine p-nitrobenzoateCalmodulinCaMCalcium-Modulated Proteincalmodulin antagonistMLCKanti-leukemia activitiesInhibitorinhibitorinhibit

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