2. Anti-infection
  3. Bacterial
  4. ABT-255 free base

ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis.

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ABT-255 free base

ABT-255 free base Chemical Structure

CAS No. : 186293-38-9

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ABT-255 free base Related Antibodies

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Description

ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis[1].

In Vitro

ABT-255 (0.016-0.5 μg/mL) free base shows MIC values of 0.016 μg/mL against ATCC 35801, 0.031 μg/mL against ATCC 25618, and 0.031 μg/mL against both 35837b (Ethambutol (HY-B0535)-resistant) and 35838c (Rifampin (HY-B0272)-resistant)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-255 free base Related Antibodies
In Vivo

ABT-255 (3.13-25 mg/kg, p.o., once daily, 4 weeks) free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4- to 6-week-old female CF-1 mice were intraperitoneally injected with overnight cultures of Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli JUHL, with the inoculum adjusted to approximately 100 times the 50% lethal dose[1]
Dosage: 3.13, 6.25, 12.5, 25 mg/kg
Administration: p.o. once daily for 4 weeks
Result: Reduced Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli in mice JUHL.
Animal Model: 4- to 6-week-old female CF-1 mice were intravenously injected via the caudal tail vein with approximately 107 viable M. tuberculosis cells suspended in 0.2 mL of modified 7H10 broth[1]
Dosage: 6.25, 12.5, 25 mg/kg
Administration: p.o. once daily for 4 weeks
Result: Produced a dose-responsive 0- to 5.5-log reduction in M. tuberculosis (ATCC 35801) counts in lung tissue.
Produced a dose-related 1- to 3-log reduction in viable Ethambutol (HY-B0535)-resistant M. tuberculosis (ATCC 35837) counts in lung tissue.
Produced a dose-responsive 1- to 2.5-log reduction in viable Rifampin (HY-B0272)-resistant Mycobacterium tuberculosis (ATCC 35838) counts in lung tissue.
Molecular Weight

385.43

Formula

C21H24FN3O3
CAS No.
SMILES

O=C(C1=CC(C2CC2)=C3C(C)=C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)C(F)=CN3C1=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ABT-255 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-255186293-38-9ABT255ABT 255Bacterialpulmonary tuberculosisS. aureusS. pneumoniaeE. coliMycobacterium tuberculosisInhibitorinhibitorinhibit

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