2. Others Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation PI3K/Akt/mTOR Apoptosis GPCR/G Protein MAPK/ERK Pathway NF-κB
  3. Akt p38 MAPK Reactive Oxygen Species (ROS) Histamine Receptor Endogenous Metabolite Apoptosis Isotope-Labeled Compounds
  4. Histamine-d4

Histamine-d4 (Ergamine-d4) is deuterium labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

For research use only. We do not sell to patients.

Histamine-d<sub>4</sub> Chemical Structure

Histamine-d4 Chemical Structure

CAS No. : 751471-48-4

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Histamine-d4 Related Antibodies

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Akt Akt1 Akt2 Akt3

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

Histamine-d4 (Ergamine-d4) is deuterium labeled Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Histamine-d4 Related Antibodies
Molecular Weight

115.17

Formula

C5H5D4N3
CAS No.
Unlabeled CAS
SMILES

NC([2H])([2H])C([2H])([2H])C1=CN=CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Histamine-d4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Histamine-d4751471-48-4Ergamine-d4Aktp38 MAPKReactive Oxygen Species (ROS)Histamine ReceptorEndogenous MetaboliteApoptosisIsotope-Labeled CompoundsPKBProtein kinase Banalytical standardorganic nitrogenimmune responsesintestinal physiological functionsneurotransmitterInhibitorinhibitorinhibit

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