2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage Others
  3. Proton Pump TOPK Isotope-Labeled Compounds
  4. Ilaprazole-d3

Ilaprazole-d3 (IY-81149-d3) is deuterium-labeled Ilaprazole (HY-101664).

For research use only. We do not sell to patients.

Ilaprazole-d<sub>3</sub> Chemical Structure

Ilaprazole-d3 Chemical Structure

CAS No. : 1070969-17-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Ilaprazole-d3:

Ilaprazole-d3 Related Antibodies

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Description

Ilaprazole-d3 (IY-81149-d3) is deuterium-labeled Ilaprazole (HY-101664)[1].

In Vitro

Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ilaprazole-d3 Related Antibodies
In Vivo

Isotopic labels can non-invasively track the distribution, transformation and clearance of compounds and their metabolites in the body through techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), which is beneficial to the study of pharmacometabolic kinetics (ADME).
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

369.46

Formula

C19H15D3N4O2S
CAS No.
Unlabeled CAS
SMILES

O=S(CC1=NC=CC(OC([2H])([2H])[2H])=C1C)C2=NC3=C(N2)C=C(N4C=CC=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (94.73 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 5 mg/mL (13.53 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7067 mL 13.5333 mL 27.0665 mL
5 mM 0.5413 mL 2.7067 mL 5.4133 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.7067 mL 13.5333 mL 27.0665 mL 67.6663 mL
5 mM 0.5413 mL 2.7067 mL 5.4133 mL 13.5333 mL
10 mM 0.2707 mL 1.3533 mL 2.7067 mL 6.7666 mL
DMSO 15 mM 0.1804 mL 0.9022 mL 1.8044 mL 4.5111 mL
20 mM 0.1353 mL 0.6767 mL 1.3533 mL 3.3833 mL
25 mM 0.1083 mL 0.5413 mL 1.0827 mL 2.7067 mL
30 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2555 mL
40 mM 0.0677 mL 0.3383 mL 0.6767 mL 1.6917 mL
50 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3533 mL
60 mM 0.0451 mL 0.2256 mL 0.4511 mL 1.1278 mL
80 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8458 mL
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Ilaprazole-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilaprazole-d31070969-17-3IY-81149-d3Proton PumpTOPKIsotope-Labeled CompoundsT-LAK cell-originated protein kinaseInhibitorinhibitorinhibit

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