CRBN ligand-109

Cat. No.: HY-W440247 Purity: ≥98.0%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

CRBN ligand-109 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-109 Chemical Structure

CAS No. : 2758533-77-4

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
References
Customer Review

Description

CRBN ligand-109 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.09

Formula

C₁₁H₈BrF₂NO₂

CAS No.

2758533-77-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=C(F)C=C(Br)C=C1F)CC2)NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (328.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2885 mL	16.4425 mL	32.8850 mL
5 mM	0.6577 mL	3.2885 mL	6.5770 mL
10 mM	0.3289 mL	1.6443 mL	3.2885 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (179 KB) CNMR (163 KB) LCMS (129 KB)

Handling Instructions (2659 KB)

References

[1]. Miletić N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2885 mL	16.4425 mL	32.8850 mL	82.2125 mL
	5 mM	0.6577 mL	3.2885 mL	6.5770 mL	16.4425 mL
	10 mM	0.3289 mL	1.6443 mL	3.2885 mL	8.2213 mL
	15 mM	0.2192 mL	1.0962 mL	2.1923 mL	5.4808 mL
	20 mM	0.1644 mL	0.8221 mL	1.6443 mL	4.1106 mL
	25 mM	0.1315 mL	0.6577 mL	1.3154 mL	3.2885 mL
	30 mM	0.1096 mL	0.5481 mL	1.0962 mL	2.7404 mL
	40 mM	0.0822 mL	0.4111 mL	0.8221 mL	2.0553 mL
	50 mM	0.0658 mL	0.3289 mL	0.6577 mL	1.6443 mL
	60 mM	0.0548 mL	0.2740 mL	0.5481 mL	1.3702 mL
	80 mM	0.0411 mL	0.2055 mL	0.4111 mL	1.0277 mL
	100 mM	0.0329 mL	0.1644 mL	0.3289 mL	0.8221 mL

CRBN ligand-109 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-1092758533-77-4CRBN ligand109CRBN ligand 109Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *