2. PROTAC Epigenetics
  3. Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain
  4. JQ-1-Azidopropylamine

JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975).

For research use only. We do not sell to patients.

JQ-1-Azidopropylamine

JQ-1-Azidopropylamine Chemical Structure

CAS No. : 2915642-70-3

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JQ-1-Azidopropylamine Related Antibodies

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Description

JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975)[1].

IC50 & Target[1]

BRD4

 

Molecular Weight

482.99

Formula

C22H23ClN8OS
CAS No.
SMILES

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCN=[N+]=[N-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (414.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0704 mL 10.3522 mL 20.7044 mL
5 mM 0.4141 mL 2.0704 mL 4.1409 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0704 mL 10.3522 mL 20.7044 mL 51.7609 mL
5 mM 0.4141 mL 2.0704 mL 4.1409 mL 10.3522 mL
10 mM 0.2070 mL 1.0352 mL 2.0704 mL 5.1761 mL
15 mM 0.1380 mL 0.6901 mL 1.3803 mL 3.4507 mL
20 mM 0.1035 mL 0.5176 mL 1.0352 mL 2.5880 mL
25 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0704 mL
30 mM 0.0690 mL 0.3451 mL 0.6901 mL 1.7254 mL
40 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2940 mL
50 mM 0.0414 mL 0.2070 mL 0.4141 mL 1.0352 mL
60 mM 0.0345 mL 0.1725 mL 0.3451 mL 0.8627 mL
80 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
100 mM 0.0207 mL 0.1035 mL 0.2070 mL 0.5176 mL
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JQ-1-Azidopropylamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JQ-1-Azidopropylamine2915642-70-3Target Protein Ligand-Linker ConjugatesEpigenetic Reader DomainTarget Protein Ligand-Linker ConjugateBRD4Inhibitorinhibitorinhibit

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