2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2 degrader-34

PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: < 0.1 μM for SMARCA2, > 1 μM for SMARCA4). PROTAC SMARCA2 degrader-34 can be used for study of cancer. (Pink: SMARCA2 ligand (HY-178414) ; Blue: E3 ligand (HY-168055) ; Black: linker).

For research use only. We do not sell to patients.

PROTAC SMARCA2 degrader-34

PROTAC SMARCA2 degrader-34 Chemical Structure

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PROTAC SMARCA2 degrader-34 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SMARCA2 degrader-34 (compound 52) is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: < 0.1 μM for SMARCA2, > 1 μM for SMARCA4). PROTAC SMARCA2 degrader-34 can be used for study of cancer. (Pink: SMARCA2 ligand (HY-178414) ; Blue: E3 ligand (HY-168055) ; Black: linker)[1].

Molecular Weight

810.87

Formula

C42H45F3N10O4
SMILES

FC([C@]12N(C[C@H](N3C4=C(CN(CC5CCN(C6=CC=C(CN([C@@H]7C(NC(CC7)=O)=O)C8=O)C8=C6)CC5)C(C)C4)C=N3)C2)C9=CC(C%10=C(C(F)=CC=C%10)O)=NN=C9NC1)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-34PROTACsEpigenetic Reader Domainhela cellsLung cancermelanomaliver cancerpancreatic cancerInhibitorinhibitorinhibit

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