2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Succinic acid-Pomalidomide

Succinic acid-Pomalidomide is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT (HY-168543).

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Succinic acid-Pomalidomide

Succinic acid-Pomalidomide Chemical Structure

CAS No. : 2417174-32-2

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Based on 1 publication(s) in Google Scholar

Succinic acid-Pomalidomide Related Antibodies

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Description

Succinic acid-Pomalidomide is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT (HY-168543)[1].

Molecular Weight

373.32

Formula

C17H15N3O7
CAS No.
Appearance

Solid

Color

off-white

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (133.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6787 mL 13.3933 mL 26.7867 mL
5 mM 0.5357 mL 2.6787 mL 5.3573 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6787 mL 13.3933 mL 26.7867 mL 66.9667 mL
5 mM 0.5357 mL 2.6787 mL 5.3573 mL 13.3933 mL
10 mM 0.2679 mL 1.3393 mL 2.6787 mL 6.6967 mL
15 mM 0.1786 mL 0.8929 mL 1.7858 mL 4.4644 mL
20 mM 0.1339 mL 0.6697 mL 1.3393 mL 3.3483 mL
25 mM 0.1071 mL 0.5357 mL 1.0715 mL 2.6787 mL
30 mM 0.0893 mL 0.4464 mL 0.8929 mL 2.2322 mL
40 mM 0.0670 mL 0.3348 mL 0.6697 mL 1.6742 mL
50 mM 0.0536 mL 0.2679 mL 0.5357 mL 1.3393 mL
60 mM 0.0446 mL 0.2232 mL 0.4464 mL 1.1161 mL
80 mM 0.0335 mL 0.1674 mL 0.3348 mL 0.8371 mL
100 mM 0.0268 mL 0.1339 mL 0.2679 mL 0.6697 mL
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Succinic acid-Pomalidomide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Succinic acid-Pomalidomide2417174-32-2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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