2. Apoptosis MAPK/ERK Pathway PI3K/Akt/mTOR Metabolic Enzyme/Protease Autophagy Others
  3. Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
  4. Guggulsterone (Standard)

Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

For research use only. We do not sell to patients.

Guggulsterone (Standard)

Guggulsterone (Standard) Chemical Structure

CAS No. : 95975-55-6

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5 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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25 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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Information

Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

312.45

Formula

C21H28O2
CAS No.
SMILES

C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Guggulsterone (Standard) Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guggulsterone (Standard)95975-55-6ApoptosisJNKAktCaspaseFXRAutophagyReference Standardsc-Jun N-terminal kinasePKBProtein kinase BNR1H4Inhibitorinhibitorinhibit

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