2. PROTAC Stem Cell/Wnt JAK/STAT Signaling
  3. PROTACs STAT
  4. AK-1690

AK-1690 is a potent and selective STAT6 PROTAC degrader. AK-1690 reduces the levels of STAT6 protein in cells (DC50=1 nM) and depletes STAT6 protein in mouse tissues. AK-1690 can be used for the research of cancer. (Pink: ligand for target protein STAT6 (HY-169182); Black: linker (HY-W459522); Blue: ligand for E3 ligase (HY-131318).

For research use only. We do not sell to patients.

AK-1690 Chemical Structure

AK-1690 Chemical Structure

CAS No. : 2984505-88-4

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AK-1690 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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STAT3 STAT5 STAT6 STAT1

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Description

AK-1690 is a potent and selective STAT6 PROTAC degrader. AK-1690 reduces the levels of STAT6 protein in cells (DC50=1 nM) and depletes STAT6 protein in mouse tissues. AK-1690 can be used for the research of cancer. (Pink: ligand for target protein STAT6 (HY-169182); Black: linker (HY-W459522); Blue: ligand for E3 ligase (HY-131318)[1].

Molecular Weight

1016.05

Formula

C51H56F2N5O11PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N4C[C@@H](C5=CC=CC=C5)OCC4)=O)C[C@H](OCCCCCC#CC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)C3)=O)=O)S2)=C1)(P(O)(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (98.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9842 mL 4.9210 mL 9.8420 mL
5 mM 0.1968 mL 0.9842 mL 1.9684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9842 mL 4.9210 mL 9.8420 mL 24.6051 mL
5 mM 0.1968 mL 0.9842 mL 1.9684 mL 4.9210 mL
10 mM 0.0984 mL 0.4921 mL 0.9842 mL 2.4605 mL
15 mM 0.0656 mL 0.3281 mL 0.6561 mL 1.6403 mL
20 mM 0.0492 mL 0.2461 mL 0.4921 mL 1.2303 mL
25 mM 0.0394 mL 0.1968 mL 0.3937 mL 0.9842 mL
30 mM 0.0328 mL 0.1640 mL 0.3281 mL 0.8202 mL
40 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6151 mL
50 mM 0.0197 mL 0.0984 mL 0.1968 mL 0.4921 mL
60 mM 0.0164 mL 0.0820 mL 0.1640 mL 0.4101 mL
80 mM 0.0123 mL 0.0615 mL 0.1230 mL 0.3076 mL
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AK-1690 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK-16902984505-88-4AK1690AK 1690PROTACsSTATcancerInhibitorinhibitorinhibit

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