2. PI3K/Akt/mTOR
  3. Akt
  4. AKT1-IN-9

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively.

For research use only. We do not sell to patients.

AKT1-IN-9 Chemical Structure

AKT1-IN-9 Chemical Structure

Size Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Check price and availability
Solid
5 mg Check price and availability
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25 mg Check price and availability

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AKT1-IN-9 Related Antibodies

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Description

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively[1].

IC50 & Target[1]

AKT1(E17K)

 

In Vivo

AKT1-IN-9 (4) (40 mg/kg, i.p. injection, single dose) reduces phospho-AKT1 and phospho-PRAS40 levels in tumours collected at 2 h and 7 h postdose (80-90% inhibition)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

572.59

Formula

C33H25FN6O3
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(CC1=CC=C(C([H])=O)C(O)=C1F)NCC(C=C2)=CC=C2N3C(C4=C(N)N=CC=C4)=NC5=C3N=C(C=C5)C6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (174.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7465 mL 8.7323 mL 17.4645 mL
5 mM 0.3493 mL 1.7465 mL 3.4929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7465 mL 8.7323 mL 17.4645 mL 43.6613 mL
5 mM 0.3493 mL 1.7465 mL 3.4929 mL 8.7323 mL
10 mM 0.1746 mL 0.8732 mL 1.7465 mL 4.3661 mL
15 mM 0.1164 mL 0.5822 mL 1.1643 mL 2.9108 mL
20 mM 0.0873 mL 0.4366 mL 0.8732 mL 2.1831 mL
25 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7465 mL
30 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4554 mL
40 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0915 mL
50 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.8732 mL
60 mM 0.0291 mL 0.1455 mL 0.2911 mL 0.7277 mL
80 mM 0.0218 mL 0.1092 mL 0.2183 mL 0.5458 mL
100 mM 0.0175 mL 0.0873 mL 0.1746 mL 0.4366 mL
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AKT1-IN-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT1-IN-9AktPKBProtein kinase BAKT1E17KLAPC4-CRSkBr3Inhibitorinhibitorinhibit

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