MRP4 Antibody (YA3530)

MRP4 Antibody (YA3530) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ABCC4. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

ABCC4 protein, a member of the ATP-binding cassette (ABC) family, operates as an ATP-dependent transporter responsible for actively extruding both physiological compounds and xenobiotics from cells. It exhibits versatility in transporting endogenous molecules crucial for cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. ABCC4 also plays a role in the ATP-dependent efflux of glutathione conjugates, such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4), with the presence of glutathione being essential for the transport of LTB4 but not LTC4. Furthermore, it mediates the cotransport of bile acids with reduced glutathione. The functional scope of ABCC4 extends to the transport of a diverse array of drugs and their metabolites, encompassing anticancer, antiviral, and antibiotic molecules, thereby conferring resistance to certain anticancer agents, including methotrexate.

O15439

Predicted band size: 150 kDa; Observed band size: 150 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ABCC4 (AA: 631-692) expressed in E. Coli.