Creosol-d₄  (Synonyms: 2-Methoxy-4-methylphenol-d₄)

Creosol-d₄ (2-Methoxy-4-methylphenol-d₄) is the deuterium labeled Creosol (HY-W040971). Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable^[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

142.19

C₈H₆D₄O₂

20189-08-6

93-51-6

COC1=C(C([2H])=C([2H])C(C)=C1[2H])O[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yin J, et al. Purification of creosol applying green heterogeneous extraction technology[J]. Journal of Chemical Technology & Biotechnology, 2022, 97(10): 2945-2951.

  [2]. Meylemans HA, Groshens TJ, Harvey BG. Synthesis of renewable bisphenols from creosol. ChemSusChem. 2012 Jan 9;5(1):206-10.  [Content Brief]

  [3]. Aliu E, et al. Mild-Temperature hydrodeoxygenation of vanillin a typical bio-oil model compound to Creosol a potential future biofuel[J]. Catalysis Today, 2021, 379: 70-79.

  [4]. Lee JH, et al., Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis. Mar Drugs. 2018 Apr 6;16(4):121.  [Content Brief]

  [5]. Tevzadze G, et al. Gut neurotoxin p-cresol induces brain-derived neurotrophic factor secretion and increases the expression of neurofilament subunits in PC-12 cells. AIMS Neurosci. 2021 Dec 23;9(1):12-23.  [Content Brief]

  [6]. Bermudez-Martin P, et al., The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021 Jul 8;9(1):157.  [Content Brief]

  [7]. Chang MC, et al., Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Atherosclerosis. 2011 Dec;219(2):559-65.  [Content Brief]