2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. Endogenous Metabolite Reactive Oxygen Species (ROS) FAK Akt ERK p38 MAPK
  4. Creosol

Creosol  (Synonyms: 2-Methoxy-4-methylphenol)

Cat. No.: HY-W040971 Purity: 99.38%
COA
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Handling Instructions Technical Support

Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable.

For research use only. We do not sell to patients.

Creosol

Creosol Chemical Structure

CAS No. : 93-51-6

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Creosol:

Creosol Related Antibodies

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable[1][2][3].

In Vitro

Creosol (50-500 μM, 72 h) is a uremic toxin that induces cellular senescence, thereby leading to impaired function of mesenchymal stem cells (MSCs) through FAK-Akt-TWIST signaling pathway[4].
Creosol is a neurotoxin at high concentration, and alters the neurometabolism at low concentration. Creosol (1 µM, 5 days) promotes the neural differentiation and BDNF secretion in cell PC-12[5].
Creosol (0-20 µM, 15 min) inhibits ROS generation and ERK/p38 signaling pathway, blocking thereby the Arachidonic acid (HY-109590)-induced platelet aggregation[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Creosol Related Antibodies

Western Blot Analysis[4]

Cell Line: mesenchymal stem cell
Concentration: 500 μM
Incubation Time: 72 h
Result: Increased expression of pro-senescence marker p21.
In Vivo

Creosol (50 mg/kg, po for 4 weeks) alters the composition of the intestinal microbiota, and induces autistic-like behaviors in mouse models[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbits[1]
Dosage: 100 mg/kg
Administration: daily dietary administration,
Result: Induced skeletal and external variations (o-cresol) and initial teratogenic effects (m-cresol) in rabbits.
Animal Model: Male Wistar rats[1]
Dosage: a mixture of m-cresol (160 mg/kg) and p-cresol (100 mg/kg)
Administration: a single gavage dose
Result: 50% of the administered doses of m-cresol and p-cresol were still found in the stomach after 15 minutes, while these were no longer detected after 8 hours in rats.
Animal Model: C57BL/6J mouse models[6]
Dosage: 50 mg/kg
Administration: Drinking water for 4 weeks
Result: Induced social behavior deficits, altered intestinal microbiota.
Molecular Weight

138.17

Formula

C8H10O2
CAS No.
Appearance

Liquid (Density: 1.092 g/cm3)

Color

Colorless to light yellow

SMILES

OC1=CC=C(C)C=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (723.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2375 mL 36.1873 mL 72.3746 mL
5 mM 1.4475 mL 7.2375 mL 14.4749 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (18.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (18.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (249 KB) HNMR (119 KB) GC (75 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.2375 mL 36.1873 mL 72.3746 mL 180.9365 mL
5 mM 1.4475 mL 7.2375 mL 14.4749 mL 36.1873 mL
10 mM 0.7237 mL 3.6187 mL 7.2375 mL 18.0937 mL
15 mM 0.4825 mL 2.4125 mL 4.8250 mL 12.0624 mL
20 mM 0.3619 mL 1.8094 mL 3.6187 mL 9.0468 mL
25 mM 0.2895 mL 1.4475 mL 2.8950 mL 7.2375 mL
30 mM 0.2412 mL 1.2062 mL 2.4125 mL 6.0312 mL
40 mM 0.1809 mL 0.9047 mL 1.8094 mL 4.5234 mL
50 mM 0.1447 mL 0.7237 mL 1.4475 mL 3.6187 mL
60 mM 0.1206 mL 0.6031 mL 1.2062 mL 3.0156 mL
80 mM 0.0905 mL 0.4523 mL 0.9047 mL 2.2617 mL
100 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8094 mL
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Creosol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Creosol93-51-62-Methoxy-4-methylphenolEndogenous MetaboliteReactive Oxygen Species (ROS)FAKAktERKp38 MAPKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePKBProtein kinase BExtracellular signal regulated kinasesendogenous metabolitebiofuellignocellulosic biomassligninbisphenol?A replacementsInhibitorinhibitorinhibit

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