2. PROTAC Metabolic Enzyme/Protease JAK/STAT Signaling Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. PROTACs Phosphatase JAK IFNAR MHC
  4. TP1L

TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)).

For research use only. We do not sell to patients.

TP1L

TP1L Chemical Structure

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TP1L Related Antibodies

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MHC I MHC II

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Description

TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002))[1].

In Vitro

TP1L (0.5-4000 nM, 3-24 h) selectively degrades TC-PTP depends on the ubiquitination-proteasome pathway (DC50 = 35.8 nM) in HEK293 cells[1].
TP1L (< 10 μM) shows no significant inhibition towards other PTPs even at up to 10 μM TP1L concentration[1].
TP1L (3.9-4000 nM, 16 h) selectively enhances IFN-γ signaling and promotes antigen presentation in HEK293 cells[1].
TP1L (62.5-1000 nM, 16 h) elevates pLCK in Jurkat T-cells and enhances CAR-T cells killing efficiency in a KB tumor/CAR-T cell coculture system [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TP1L Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells and Jurkat T-cells
Concentration: 0.5, 3.9, 7.8, 15.6, 31.2, 62.5, 125, 250, 500, 1000, 2000, 4000 nM
Incubation Time: 3, 6, 16, 24 h
Result: Degradated TC-PTP with a DC50 of 35.8 nM in HEK293 cells after 16 hours of treatment.
Showed no signicantly altered on the level of PTP1Bat up to 4 mM concentration.
Degradated TC-PTP completly within 6 hours.
Did not decrease during the entire period of TP1L treatment.
Enhanced the levels of pJAK1 and pSTAT1.
Did not affected the phosphorylation level of JAK2, which is a substrate of PTP1B.
Degraded TC-PTP and promoted phosphorylation of LCK in Jurkat T-cells.
Molecular Weight

1255.34

Formula

C64H81F2N8O14P
SMILES

FC(C1=CC=C(C[C@H](NC([C@@H](NC(CO[C@@H]2[C@@H](C(C)C)CC[C@H](C)C2)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC=C(CC)C=C4)=O)C(NCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)=O)=O)C=C1)(P(O)(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TP1L Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP1LPROTACsPhosphataseJAKIFNARMHCJanus kinaseInterferon-α/β receptorInterferon-alpha/beta receptor Major Histocompatibility ComplexTC-PTPSTAT1JAK1IFN-γ signalingCAR-T cellsInhibitorinhibitorinhibit

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