ApoE Antibody (YA1516)

Cat. No.: HY-P81771: Data Sheet COA
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ApoE Antibody (YA1516) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1516), targeting ApoE, with a predicted molecular weight of 36 kDa. ApoE Antibody (YA1516) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	ApoE Antibody (YA1516) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1516), targeting ApoE, with a predicted molecular weight of 36 kDa. ApoE Antibody (YA1516) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse background.
Background	ApoE is an apolipoprotein that primarily mediates lipoprotein-dependent lipid transport between organs through plasma and interstitial fluids. As a core component of plasma lipoproteins, it participates in their production, conversion, and clearance. This amphipathic protein interacts with both lipoprotein core lipids and the aqueous plasma environment, showing preferential binding to HDL while also associating with chylomicrons, chylomicron remnants, VLDL, and IDL. ApoE facilitates cellular uptake of lipoprotein particles by binding receptors such as LDLR, LRP1, LRP2, LRP8, and VLDLR. Its heparin-binding activity enables interaction with cell surface heparan-sulfate proteoglycans, promoting lipoprotein capture and receptor-mediated endocytosis. A key function involves hepatic clearance of chylomicrons, VLDL, and HDL, as well as VLDL biosynthesis and peripheral tissue uptake for triglyceride delivery. In reverse cholesterol transport, ApoE collaborates with ABCA1 in HDL biogenesis and mediates hepatocyte uptake of circulating HDL. Within the central nervous system, it regulates neuronal survival and sprouting. ApoE contributes to innate and adaptive immune responses (By similarity), including modulation of myeloid-derived suppressor cell survival, and binds immune receptor LILRB4. It may also influence transcription via a receptor-dependent, cholesterol-independent mechanism activating MAP3K12 and non-canonical MAPK signaling to enhance AP-1-mediated APP transcription. During microbial infection, ApoE interacts with HCV envelope glycoprotein E2 to facilitate viral attachment to HSPGs and other receptors (LDLr, VLDLr, SR-B1) on host cells, supporting HCV particle assembly, maturation, and infectivity.
Gene ID	7804 [NCBI]
SwissProt ID	P02649
Synonyms	APOE; Apolipoprotein E; Apo-E
Molecular Weight	Predicted band size: 36 kDa; Observed band size: 36 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3103136
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse
Dilution Ratio	WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/50
Application	WB, IHC-P, ICC/IF, IP
Appearance	Liquid
Formulation	Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human Apolipoprotein E
Database	Entrez Gene: 7804 Human ; 16975 Mouse ; 362558 Rat SwissProt: Q14114 Human ; Q924X6 Mouse ; OMIM: 608446 Human
Documentation	Select Batch: Data Sheet (236 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

ApoE Antibody (YA1516) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ApoE Antibody (YA1516)

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