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  4. 1,2-Cyclohexylenedinitrilotetraacetic acid

1,2-Cyclohexylenedinitrilotetraacetic acid  (Synonyms: CDTA)

Cat. No.: HY-W102714 Purity: ≥98.0%
SDS
COA
Handling Instructions Technical Support

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate.

For research use only. We do not sell to patients.

1,2-Cyclohexylenedinitrilotetraacetic acid Chemical Structure

1,2-Cyclohexylenedinitrilotetraacetic acid Chemical Structure

CAS No. : 482-54-2

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Other Forms of 1,2-Cyclohexylenedinitrilotetraacetic acid:

1,2-Cyclohexylenedinitrilotetraacetic acid Related Antibodies

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Description

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate[1].

In Vitro

1,2-Cyclohexylenedinitrilotetraacetic acid is an analogue of EDTA, with the vinyl group replaced by a cyclohexenyl group and the two aminoacetic acid groups in a trans configuration. 1,2-Cyclohexylenedinitrilotetraacetic acid exhibits stronger lipophilicity and pre-organization ability, and forms more stable complex with metal ions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,2-Cyclohexylenedinitrilotetraacetic acid Related Antibodies
In Vivo

1,2-Cyclohexylenedinitrilotetraacetic acid (36 mg/kg, ip, once a day for two days) alleviates manganese-induced acute neurotoxicity in Sprague-Dawley rats models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Manganese-induced acute neurotoxicity in Sprague-Dawley rats models[3]
Dosage: 36 mg/kg
Administration: ip, once a day for two days
Result: Reduced the manganese ion concentration in the brain tissue, prevented the occurance of pathological changes such as Alzheimer's type II astrocyte proliferation.
Molecular Weight

346.33

Formula

C14H22N2O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1CCC(C(C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5.83 mg/mL (16.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8874 mL 14.4371 mL 28.8742 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (254 KB) HNMR (257 KB) MS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8874 mL 14.4371 mL 28.8742 mL 72.1855 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL 14.4371 mL
10 mM 0.2887 mL 1.4437 mL 2.8874 mL 7.2185 mL
15 mM 0.1925 mL 0.9625 mL 1.9249 mL 4.8124 mL
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1,2-Cyclohexylenedinitrilotetraacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2-Cyclohexylenedinitrilotetraacetic acid482-54-2CDTABiochemical Assay ReagentsSprague-Dawley ratEDTAInhibitorinhibitorinhibit

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