2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-186

CRBN ligand-186 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-186 Chemical Structure

CRBN ligand-186 Chemical Structure

CAS No. : 3084710-09-5

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CRBN ligand-186 Related Antibodies

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View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

CRBN ligand-186 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC[1].

Molecular Weight

967.03

Formula

C44H48F2N8O11S2
CAS No.
SMILES

N#CC(C(NS(=O)(N(CC)C)=O)=CC=C1F)=C1OC(C=C2C3=O)=CC=C2N=CN3[C@@H]4COC5(C4)CCN(CC5)C(CN6CCC(CC6)C7=CC=C(C=C7OS(=O)(F)=O)C8CCC(NC8=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CRBN ligand-186 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-1863084710-09-5CRBN ligand186CRBN ligand 186Ligands for E3 LigaseE3 ligase-recruiting MoietyCRBN ligandE3 ubiquitin ligasePROTACInhibitorinhibitorinhibit

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CRBN ligand-186
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HY-174249
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