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Pathways Recommended:	GPCR/G Protein

Results for "

Gly

" in MedChemExpress (MCE) Product Catalog:

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5678

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

158

Biochemical Assay Reagents

3036

Peptides

MCE Kits

128

Inhibitory Antibodies

500

Natural
Products

162

Isotope-Labeled Compounds

Click Chemistry

254

Oligonucleotides

**Gly-Gly-Phe-Gly**	Drug Intermediate	Cancer
Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates .

Gly-Gly-Gly-PEG4-DBCO	ADC Linker	Cancer
Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Gly-Gly-Gly-PEG2-azide	ADC Linker	Cancer
Gly-Gly-Gly-PEG2-azide is an ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs) .

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan	ADC Cytotoxin	Cancer
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC cytotoxin.

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ～5 and ～6.5 μM

Gly-Gly-Gly-PEG3-TCO	ADC Linker	Cancer
Gly-Gly-Gly-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan hydrochloride	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan, as a drug-linker conjugate composed of linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, can be used to prepare antibody conjugate drugs. Exatecan is a DNA topoisomerase I inhibitor that can be used in cancer research .

Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan is used for ADC Synthesis .

Gly-Gly-AMC	Fluorescent Dye	Others
Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .

Gly-Gly-Gly-PEG4-methyltetrazine	ADC Linker	Cancer
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Gly-Gly-Gly-PEG4-azide	ADC Linker	Cancer
Gly-Gly-Gly-PEG4-azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Gly-Gly-Gly-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

Gly-d-Phe	Carboxypeptidase	Others
Gly-d-Phe is an affinity ligand for Thermolysin (HY-P1748) . Gly-d-Phe can be used as the substrate of membrane dipeptidase (MDP) .

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

Gly6 HexaGlycine	Bacterial	Others
Gly6 (Hexaglycine) is a linear glycine oligopeptide with six glycines .

Gly-Arg-AMC	Dipeptidyl Peptidase	Others
Gly-Arg-AMC is a peptide substrate of DPAP1 .

Gly-Arg-pNA	Fluorescent Dye	Others
Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .

Gly-Ala H-Gly-Ala-OH	Amino Acid Derivatives	Others
Gly-Ala is a Glycine (HY-Y0966) derivative .

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

Gly3-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs) .

Gly-7-MAD-MDCPT	ADC Cytotoxin Topoisomerase	Cancer
Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC₅₀ values of 10-1000 nM .

Gly-(S)-Cyclopropane-Exatecan	Drug Isomer	Others
Gly-(S)-Cyclopropane-Exatecan is the isomer of Gly-Cyclopropane-Exatecan (HY-148696A).

Gly-Pro-AMC	Biochemical Assay Reagents	Others
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)

Gly-Asp	Amino Acid Derivatives	Others
Gly-Asp is a Glycine (HY-Y0966) derivative .

Gly-Asp hydrate	Amino Acid Derivatives	Others
Gly-Asp hydrate is a Glycine (HY-Y0966) derivative .

Gly-Phe-AMC	Biochemical Assay Reagents	Others
Gly-Phe-AFC is a fluorescent substrate, which is a peptide sequence composed of glycine and phenylalanine, linked to the fluorescent group AFC .

Gly-Pro-pNA hydrochloride	Dipeptidyl Peptidase	Others
Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors .

*H-Gly-Arg-pNA hydrochloride* Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride	Fluorescent Dye	Others
H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity .

Gly-β-MCA (Standard)	FXR Autophagy	Metabolic Disease
Gly-β-MCA (Standard) is the analytical standard of Gly-β-MCA. This product is intended for research and analytical applications. Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders[1].

*(Gly14)-Humanin (human) (acetate)* 14-Glycine-Humanin (human) (acetate)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

Gly-Sar Glycylsarcosine	Amino Acid Derivatives	Others
Gly-Sar is a Glycine (HY-Y0966) derivative .

Gly-Phe-β-naphthylamide	Cathepsin	Metabolic Disease
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .

Gly-Leu-Tyr	Amino Acid Derivatives	Others
Gly-Leu-Tyr is a Glycine (HY-Y0966) derivative .

Gly-His-Lys acetate	Biochemical Assay Reagents	Others
Gly-His-Lys acetate is a plasma tripeptide that stimulates growth and differentiation when added to cell culture systems.

*(Gly0.8Nap0.2)20*	Fungal DNA/RNA Synthesis	Infection
(Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity .

*(Gly14)-Humanin (human)* 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

Gly-Cyclopropane-Exatecan	ADC Cytotoxin Topoisomerase	Cancer
Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro .

Gly-Leu-Met-NH2	Neurokinin Receptor	Neurological Disease
Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (Substance P (HY-P0201)). Substance P is a neuropeptide .

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide .

Gly-β-MCA 10+ Cited Publications	FXR Autophagy	Metabolic Disease
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders .

Gly-PEG3-endo-BCN	PROTAC Linkers	Cancer
Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Gly-PEG3-amine	ADC Linker	Cancer
Gly-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Glycyl-L-proline (Standard) H-Gly-Pro-OH (Standard)	Endogenous Metabolite	Metabolic Disease
H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dye	Others
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

*(Gly22)-Amyloid β-Protein (1-42)*	Amyloid-β	Neurological Disease
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation .

Cat. No.	Product Name

HY-L0120V

Asinex BioDesign Library

170,269 compounds

“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.

Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

HY-L0116V

Asinex Macrocycles for RNA Library

1,065 compounds

Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.

HY-L006

GPCR/G Protein Compound Library

2,895 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 2,895 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

HY-L165

Dopamine Receptor Compound Library

235 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 235 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

HY-L206

High-Throughput Natural Product Library

4,661 compounds

Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules.

MCE provides a unique collection of 4,661 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

HY-L120

GABA Receptor Compound Library

170 compounds

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). GABA receptors are significant drug targets in the treatment of neuropsychiatric disorders such as epilepsy, insomnia, and anxiety, as well as in anesthesia in surgical operations.

MCE offers a unique collection of 170 GABA receptors inhibitors and activators, which is an efficient tool for neuropsychiatric disorders drugs discovery.

HY-L033

Peptidomimetic Library

372 compounds

Peptidomimetics are compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect. Peptidomimetics are designed to circumvent some of the problems associated with a natural peptide: e.g. stability against proteolysis (duration of activity) and poor bioavailability. Certain other properties, such as receptor selectivity or potency, often can be substantially improved. The design and synthesis of peptidomimetics are most important because of the dominant position peptide and protein-protein interactions play in molecular recognition and signaling, especially in living systems. Hence mimics have great potential in drug discovery.

MCE Peptidomimetic Library contains 372 compounds including peptoid, α-helix mimetics, β-turn/sheets mimetics, etc. This library is an indispensable tool of structure-activity relationships in drug discovery.

HY-L022M

FDA-Approved Drug Library Mini

3,069 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 3,069 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.

HY-L150

Membrane Receptor-targeted Compound Library

5,814 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 5,814 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L121

5-HT Receptor Compound Library

356 compounds

5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

MCE 5-HT Receptor Compound Library consists of 356 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

HY-L082

Antiparasitic Compound library

544 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 544 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

HY-L088

Angiogenesis-Related Compound Library

2,670 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 2,670 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

HY-L062

Neurotransmitter Receptor Compound Library

2,170 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 2,170 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

HY-L132

Chemokine Compound Library

190 compounds

Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.

The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.

MCE supplies a unique collection of 190 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

HY-L076

Drug-Induced Liver Injury (DILI) Compound Library

1,447 compounds

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1,447 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

HY-L018

TGF-beta/Smad Compound Library

331 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 331 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L013

Neuronal Signaling Compound Library

3,194 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 3,194 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Type

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dyes/Probes
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

HY-P0019

*Z-Gly-Gly-Arg-AMC* 5+ Cited Publications	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

HY-P0019A

*Z-Gly-Gly-Arg-AMC acetate* 5+ Cited Publications	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

HY-W010991

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

FAPGG

Chromogenic Substrates Amino acids and Derivatives

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 ^-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .

HY-D1670

*Z-Gly-Pro-AMC*	Chromogenic Substrates
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-amido-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Fluorescent Dye
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

HY-137834A

Gly-Pro-AMC	Fluorescent Dyes/Probes
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)

HY-137858

*H-Gly-Arg-pNA hydrochloride* Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride	Dyes
H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity .

HY-131833G

*Fmoc-Gly-Gly-Phe-OH (GMP)*	Fluorescent Dye
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131990G

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Fluorescent Dye
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W098721

*Z-Gly-Sar-OH*	Fluorescent Dyes/Probes
Z-Gly-Sar-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-44980G

*Fmoc-Gly-NH-CH2-acetyloxy (GMP)*	Fluorescent Dye
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

HY-D0303AR

Chrysoidine G (Standard)

Dyes

Chrysoidine G (Standard) is the analytical standard of Chrysoidine G. This product is intended for research and analytical applications. Chrysoidine G (Solvent Orange 3 hydrochloride) is an industrial azoic dye (cationic dye). Chrysoidine G (Solvent Orange 3 hydrochloride) is used for the construction of most textile dyestuffs and also in synthetic industrial compounds. Chrysoidine G (Solvent Orange 3 hydrochloride) concentration can be determined by UV-Vis spectroscopy .

HY-D0303A

Chrysoidine G Solvent Orange 3 hydrochloride	Dyes
Chrysoidine G (Solvent Orange 3 hydrochloride) is an industrial azoic dye (cationic dye). Chrysoidine G (Solvent Orange 3 hydrochloride) is used for the construction of most textile dyestuffs and also in synthetic industrial compounds. Chrysoidine G (Solvent Orange 3 hydrochloride) concentration can be determined by UV-Vis spectroscopy .

HY-D0303

Chrysoidine G free base

Solvent Orange 3; Chrysoidine Y base

Dyes

Chrysoidine G (free base) (Solvent Orange 3; Chrysoidine Y base) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

HY-D1348

BDP R6G alkyne	Fluorescent Dyes/Probes
BDP R6G alkyne is an alkyne modified BDP R6G. BDP R6G is a bright and photostable dye (BDP R6G: Ex=530 nm, Em=545 nm). BDP R6G alkyne can be used for labeling using Click chemistry.

HY-172268

R6G phosphoramidite, 6-isomer	Fluorescent Dyes/Probes
R6G phosphoramidite for oligonucleotide synthesis, pure 6-isomer. R6G (rhodamine 6G) is a xanthene dye of the rhodamine family with high fluorescence quantum yield and high molar extinction coefficient. Relative to those of fluorescein, the absorption (518 nm) and emission (542 nm) maxima of 6-R6G are shifted into the long-wave region.

HY-119987R

Sudan orange G (Standard)	Dyes
Sudan orange G (Standard) is the analytical standard of Sudan orange G. This product is intended for research and analytical applications. Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions .

HY-D1239

BODIPY R6G NHS ester	Dyes
BODIPY R6G NHS ester is a borondipyrromethene dye. BODIPY R6G NHS ester can be conjugated with proteins. BODIPY R6G NHS ester can be used for intracellular traces .

HY-D1469

5-Carboxyrhodamine 6G succinimidyl ester R6G-SE	Fluorescent Dyes/Probes
5-Carboxyrhodamine 6G succinimidyl ester (R6G-SE) is an amine reactive fluorescent dye .

HY-D1369

BDP R6G amine hydrochloride	Fluorescent Dyes/Probes
BDP R6G amine hydrochloride is a boronic dipyrromethene dye matched to the rhodamine 6G (R6G) channel. The fluorophore derivative contains an aliphatic amine group in the form of a salt. Amine groups can be conjugated to electrophiles. Amines can also be used for enzymatic transamination.

HY-D1649

BDP R6G amine	Fluorescent Dyes/Probes
BDP R6G amine is a fluorophore based on borondipyrromethene scaffold. BDP R6G amine is a BDP linker containing an amine group. BDP R6G amine is a terminal alkyne for copper-catalyzed Click chemistry. (λ_ex=530 nm, λ_em=548 nm).

HY-D1599

Rhodamine 6G hydrazide R6GH	Fluorescent Dyes/Probes
Rhodamine 6G hydrazide (R6GH) is a fluorescent dye. Rhodamine 6G hydrazide can be used in selective colorimetric and fluorescent sensing .

HY-119987

Sudan orange G SOG	Dyes
Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions .

HY-D2730

N14G-Fe	Fluorescent Dyes/Probes
N14G-Fe, the Fe ³⁺-chelated form of N14G, identifies Mtb in sputum samples with tuberculosis, exhibiting exceptional fluorescence. N14G-Fe can effectively traverse the cell wall and inner membrane region where IrtAB is located .

HY-D1330

BDP R6G azide	Fluorescent Dyes/Probes
BDP R6G azide is an anlong of BDP dye. BDP R6G azide is available that are tuned to match excitation and emission channels of classical xanthene and cyanine dyes. BDP R6G azide can be used in copper-catalyzed Click chemistry reactions with alkynes, DBCO and BCN. (λ_ex=530 nm, λ_em=548 nm) .

HY-135712

Orange G

Acid Orange GG

Dyes

Orange G is an azo dye commonly found in textile wastewater and is mainly used for textile dyeing. Orange G has a coloring function and can give textiles a specific color. The stability and potential hazards of Orange G in the environment are often used to study the removal effects of various wastewater treatment technologies on difficult-to-degrade organic pollutants, especially the degradation of azo dyes. Related research focuses on how to destroy the azo bond of Orange G through chemical, physical or biological methods to achieve harmless treatment to solve the problem of textile wastewater pollution .

HY-D1363

BDP R6G maleimide	Fluorescent Dyes/Probes
BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

HY-D2764

Difluorocarboxyfluorescein cadaverine, 5-isomer	Fluorescent Dyes/Probes
Difluorocarboxyfluorescein cadaverine, 5-isomer is a carbonyl reactive building block used to modify carboxylic groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.

HY-D1591

BODIPY R6G methyl ester

Fluorescent Dyes/Probes

BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic research, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis .

HY-D0565

Disperse blue 291G	Dyes
Disperse blue 291G is a blue dye commonly used for fiber dyeing.

HY-D0277

Eriochrome black T	Dyes
Eriochrome black T is a complex indicator used in complex titrations, e.g.

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-B0883

Proflavine hemisulfate 2 Publications Verification Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate	Fluorescent Dyes/Probes
Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent . Proflavine hemisulfate behaves as a pore blocker for K_ir3.2. Proflavine hemisulfate is a potential lead compound for K_ir3.2-associated neurological diseases .

HY-D1169

BDP R6G carboxylic acid	Fluorescent Dyes/Probes
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .

HY-D2733

N14G	Fluorescent Dyes/Probes
N14G is a fluorescent dye that can be used to stain bacteria such as Mycobacterium tuberculosis .

HY-W127705

Quinacrine mustard dihydrochloride	Fluorescent Dyes/Probes
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .

HY-135009

2-Di-1-ASP DASPI	Fluorescent Dyes/Probes
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-D0411

Xylene Fast Yellow 2G Acidyellow 17; Yellow 2G	Dyes
Xylene Fast Yellow 2G is a synthetic dye belonging to the class of azo dyes. It is commonly used in the textile industry to dye natural and synthetic fibers as well as in the paper and ink industries. Xylene Fast Yellow 2G produces a bright yellow color that is fade and wash resistant and can be applied to textiles by a variety of methods including dipping, padding and printing.

HY-113823

Naphthol AS-G	Fluorescent Dyes/Probes
Naphthol AS-G is an active compound. Naphthol ASG can be used for a series of synthetic organic pigments (SOP’s) research .

HY-129042

Cibacron Blue 3G-A 1 Publications Verification	Dyes
Cibacron Blue 3G-A is an anthraquinone dye, inhibits the R46 β-lactamase with a K_i value of 1.2 uM .

HY-D0309R

Rhodamine 6G (Standard)

Fluorescent Dyes/Probes

Rhodamine 6G (Standard) is the analytical standard of Rhodamine 6G. This product is intended for research and analytical applications. Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	Chromogenic Substrates
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-D2380

H2S probe 1	Fluorescent Dyes/Probes
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric *G-quadruplex* (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

HY-133821

N-Methylmesoporphyrin IX

Fluorescent Dyes/Probes

N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .

HY-W800807

R6G azide, 5-isomer	Fluorescent Dyes/Probes
R6G azide, 5-isomer is a xanthene dye with a terminal azide. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

HY-D2751

BP Fluor 488 cadaverine

Fluorescent Dyes/Probes

BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.

HY-D1144

Acid blue 260	Dyes
Acid blue 260 is an azo dye whose staining effect is effectively removed by multi-walled carbon nanotubes (MWCNTs). At 298 K, the adsorption capacity of MWCNT is 233.34 mg/g; and increases with the increase of dye concentration and temperature.

HY-D1906

BDP R6G NHS ester	Fluorescent Dyes/Probes
BDP R6G NHS ester is a borodipyrromethane fluorophore, which contains a NHS ester group that can react with amine groups (-NH2) in proteins or other molecules to form stable amide bonds (Ex/Em = 530/548 nm) .

HY-D0097

7-Fluorobenzofurazan-4-sulfonic acid ammonium	Fluorescent Dyes/Probes
7-Fluorobenzofurazan-4-sulfonic acid ammonium is a fluorescent label. 7-Fluorobenzofurazan-4-sulfonic acid ammonium can be used for detecting dissolved thiol-disulfide (e.g., Cys, GSH) .

Cat. No.	Product Name	Type

HY-W015236

H-Gly-Gly-Gly-OH

TriGlycine

Chelators

H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA

Biochemical Assay Reagents

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-157353

MacConkey Agar MAC	Microbial Culture
MacConkey Agar (MAC) can be used for selective isolation and culture of intestinal pathogens. The composition of 1 liter of MacConkey Agar (MAC) is: 20.0g peptone, 10.0 g lactose, 1.5 g Bile salt number three, 5.0 g sodium chloride, 0.03g Neutral red, 0.001 g Crystal viol and 15.0 g agar .

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Biochemical Assay Reagents
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

HY-W040074

Glycylglycine hydrochloride hydrate

DiGlycine hydrochloride hydrate; Gly-Gly (HCl H2O)

Buffer Reagents

Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-W015236R

H-Gly-Gly-Gly-OH (Standard)

Chelators

H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

HY-131833G

*Fmoc-Gly-Gly-Phe-OH (GMP)*	Biochemical Assay Reagents
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131990G

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Biochemical Assay Reagents
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-44980G

*Fmoc-Gly-NH-CH2-acetyloxy (GMP)*	Biochemical Assay Reagents
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-158473

FA2[3]G1 & FA2[6]G1 glycan (G1F) FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide	Carbohydrates
FA2[3]G1 & FA2[6]G1 glycan (G1F) (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158523

A2[3]G1 & A2[6]G1 glycan (G1) A2[3]G1 & A2[6]G1 N-linked oligosaccharide	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1) (A2[3]G1 & A2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158480

FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled	Carbohydrates
FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158479

FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled	Carbohydrates
FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158481

FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AA labelled	Carbohydrates
FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158520

A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled (A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158478

FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AB labelled	Carbohydrates
FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-157356

Violet Red Bile Glucose Agar	Microbial Culture
Violet Red Bile Glucose Agar can be used for counting intestinal bacteria and identification of enterobacteriaceae. The composition of 1 liter of Violet Red Bile Glucose Agar contains: 7.0 g gelatin pancreatic enzyme hydrolysate, 3.0 g yeast extract powder, 1.5 g sodium deoxycholate, 10.0 g glucose, 5.0 g sodium chloride, 0.03 g neutral red, 0.002 g crystal violet, and 15.0 g agar in per liter .

HY-157376

Casein Agar	Microbial Culture
Casein Agar can be used for casein decomposition test of Bacillus cereus. The composition of 1 liter of Casein Agar contains contains: 10.0 g casein, 3.0 g beef infusion powder, 5.0 g sodium chloride, 2.0 g dipotassium hydrogen phosphate and 15.0 g agar .

HY-158452

A3G3 glycan (G3) A3G3 N-linked oligosaccharide; A3G(4)3 Glycan	Carbohydrates
A3G3 glycan (G3) (A3G3 N-linked oligosaccharide; A3G(4)3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158442

A2G2 glycan (G2) A2G2 N-linked oligosaccharide; A2G(4)2 Glycan	Carbohydrates
A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158448

FA2G2 glycan (G2F) FA2G2 N-linked oligosaccharide; F(6)A2G2	Carbohydrates
FA2G2 glycan (G2F) (FA2G2 N-linked oligosaccharide; F(6)A2G2) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-157364

Levine Eosin-Methylene Blue Agar Medium Levine EMB Agar	Microbial Culture
Levine Eosin-Methylene Blue Agar Medium (Levine EMB Agar) is a weakly selective medium for the isolation of intestinal pathogens, especially E. coli. The composition of 1 liter of Levine Eosin-Methylene Blue Agar Medium: 10.0 g Peptone, 10.0 g lactose, 2.0 g dipotassium hydrogen phosphate, 15.0 g agar, 0.4 g eosin, 0.065 g methylene blue .

HY-D0014

Brilliant blue G-250

3 Publications Verification

Indicators

Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations are determined by the absorbance at 595 nm due to the binding of Brilliant Blue G-250 to proteins. Brilliant Blue G-250 is a safe highly selective P2×7R antagonist with promising consequent inactivation of NLRP3 inflammasome .

HY-153102

G3-CNP	Enzyme Substrates
G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .

HY-E70187

Arylsulfatase G EC:3.1.6.1; ARSG	Enzyme Substrates
Arylsulfatase G is a lysosomal sulfatase. Arylsulfatase G has a high degree of sequence similarity with all sulphatases and in particular with arylsulphatases. Arylsulfatase G can be used for the research of metabolic .

HY-158447

A2G2 glycan (G2), procainamide labelled A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 Glycan, procainamide labelled	Carbohydrates
A2G2 glycan (G2), procainamide labelled (A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158489

A3G3 glycan (G3), procainamide labelled A3G3 N-linked oligosaccharide, procainamide labelled; A3G(4)3 Glycan, procainamide labelled	Carbohydrates
A3G3 glycan (G3), procainamide labelled (A3G3 N-linked oligosaccharide, procainamide labelled; A3G(4)3 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158477

FA2G2S1 glycan (G2FS1) FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 Glycan; F(6)A2G(4)2S(6)1 Glycan	Carbohydrates
FA2G2S1 glycan (G2FS1) (FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 glycan; F(6)A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158522

A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AB labelled	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158495

A2 glycan (G0), 2-AA labelled A2 N-linked oligosaccharide, 2-AA labelled	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158451

FA2G2 glycan (G2F), APTS labelled FA2G2 N-linked oligosaccharide, APTS labelled; F(6)A2G2, APTS labelled	Carbohydrates
FA2G2 glycan (G2F), APTS labelled (FA2G2 N-linked oligosaccharide, APTS labelled; F(6)A2G2, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-152229

G0-C14	Drug Delivery
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-158506

A2G2S2 glycan (G2S2) A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 Glycan	Carbohydrates
A2G2S2 glycan (G2S2) (A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158475

A2G2S1 glycan (G2S1) A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 Glycan	Carbohydrates
A2G2S1 glycan (G2S1) (A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158476

FA2G2S1 glycan (G2FS1), procainamide labelled FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 Glycan, procainamide labelled; F(6)A2G(4)2S(6)1 Glycan, procainamide labelled	Carbohydrates
FA2G2S1 glycan (G2FS1), procainamide labelled (FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 glycan, procainamide labelled; F(6)A2G(4)2S(6)1 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158513

FA2G2S2 glycan (G2FS2) FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 Glycan	Carbohydrates
FA2G2S2 glycan (G2FS2) (FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158449

FA2G2 glycan (G2F), 2-AA labelled FA2G2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G2, 2-AA labelled	Carbohydrates
FA2G2 glycan (G2F), 2-AA labelled (FA2G2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G2, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158450

FA2G2 glycan (G2F), 2-AB labelled FA2G2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G2, 2-AB labelled	Carbohydrates
FA2G2 glycan (G2F), 2-AB labelled (FA2G2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G2, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158510

A2G2S2 glycan (G2S2), APTS labelled A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 Glycan, APTS labelled	Carbohydrates
A2G2S2 glycan (G2S2), APTS labelled (A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-156263

LB Broth Base, powder Luria-Bertani Base	Microbial Culture
LB Broth Base, powder (Luria-Bertani Base) is generally used to maintain the growth of E. coli. The composition of 1 liter of LB medium is: 10 g peptone, 5 g yeast extract and 10 g NaCl .

HY-158517

FA2G2S2 glycan (G2FS2), APTS labelled FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 Glycan, APTS labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), APTS labelled (FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-157346

LB Nutrient Agar	Microbial Culture
LB Nutrient Agar is a nutritionally rich medium originally developed for growth and maintenance of E. coli strains. LB Nutrient Agar is the most widely used medium for the growth of bacteria. The composition of 1 liter of LB Nutrient Agar contains：10.0 g tryptone, 5.0 g yeast, 10.0 g sodium chloride, and 15.0 g agar .

HY-109536B

Ammonium polyphosphate, n＜20, water solubility＞90g/100ml	Buffer Reagents
Ammonium polyphosphate, n＜20, water solubility＞90g/100ml is a biochemical assay reagent.

HY-W416274

N-β-D-Glucopyranosyloctanamide	Surfactants
Ammonium polyphosphate, n＜20, water solubility＞90g/100ml is a biochemical assay reagent.

HY-158515

FA2G2S2 glycan (G2FS2), 2-AB labelled FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 Glycan, 2-AB labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), 2-AB labelled (FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158508

A2G2S2 glycan (G2S2), 2-AA labelled A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 Glycan, 2-AA labelled	Carbohydrates
A2G2S2 glycan (G2S2), 2-AA labelled (A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158512

A2G2S2 glycan (G2S2), 2-AB labelled A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 Glycan, 2-AB labelled	Carbohydrates
A2G2S2 glycan (G2S2), 2-AB labelled (A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158518

FA2G2S2 glycan (G2FS2), 2-AA labelled FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 Glycan, 2-AA labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), 2-AA labelled (FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-NP0201

Immunoglobulin G-FITC	Native Proteins
Immunoglobulin G-FITC is a conjugate of human IgG and FITC (HY-66019). Immunoglobulin G-FITC is suitable for use in immunoaffinity purifications .

Cat. No.	Product Name	Target	Research Area

HY-W048840

Gly-Gly-Leu	Peptides	Others
Gly-Gly-Leu is a peptide with 3 amino acid.

HY-P3669

**Gly-Gly-Phe-Gly**	Drug Intermediate	Cancer
Gly-Gly-Phe-Gly is a peptide spacer and can be applied to Doxorubicin (HY-15142A) (DXR) conjugates .

HY-P0295

Gly-Arg-Gly-Asp-Ser GRGDS	Integrin	Others
Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ～5 and ～6.5 μM

HY-P4236

Gly-d-Phe	Carboxypeptidase	Others
Gly-d-Phe is an affinity ligand for Thermolysin (HY-P1748) . Gly-d-Phe can be used as the substrate of membrane dipeptidase (MDP) .

HY-111922

*H-Gly-Gly-Pro-OH* Glycyl-Glycyl-L-proline	Peptides	Others
H-Gly-Gly-Pro-OH is a peptide with 3 amino acid.

HY-P4249

Gly-Gly-Arg	Peptides	Endocrinology
Gly-Gly-Arg is a tripeptide, and a “pumping pheromone” released from the hatching eggs. Gly-Gly-Arg induces pleopod pumping activity, with the threshold concentration of 10 nM. Gly-Gly-Arg shows maximum percentage response of 58.3%. Gly-Gly-Arg act as pheromones and controlls larval release in subtidal crustaceans .

HY-P6303

**Gly-Glu-Gly**	Peptides	Others
Gly-Glu-Gly is a tripeptide, which can be used to study the protein structure, and the behavior of individual amino acid residues during folding .

HY-P4251

Gly-Phe-Gly-Aldehyde semicarbazone	Peptides	Others
Gly-Phe-Gly-Aldehyde semicarbazone is a peptide.

HY-P0295A

Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA	Integrin	Inflammation/Immunology
Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin . Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM .

HY-P0148

Gly6 HexaGlycine	Bacterial	Others
Gly6 (Hexaglycine) is a linear glycine oligopeptide with six glycines .

HY-P4342

Gly-Arg-AMC	Dipeptidyl Peptidase	Others
Gly-Arg-AMC is a peptide substrate of DPAP1 .

HY-P4465

Gly-Arg-pNA	Fluorescent Dye	Others
Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .

HY-W141910

Gly-Ala H-Gly-Ala-OH	Amino Acid Derivatives	Others
Gly-Ala is a Glycine (HY-Y0966) derivative .

HY-P0296

Gly-Phe-Arg	Peptides	Others
Gly-Phe-Arg is a superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone.

HY-117483

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

HY-P4889

*(Gly22)-amyloid beta-protein(1-40)*	Peptides	Neurological Disease
(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) is a peptide. (Gly22)-amyloid beta-protein(1-40) can be used for the research of Alzheimer's disease .

HY-137834A

Gly-Pro-AMC	Biochemical Assay Reagents	Others
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)

HY-W141911

Gly-Asp	Amino Acid Derivatives	Others
Gly-Asp is a Glycine (HY-Y0966) derivative .

HY-P4425

Gly-Phe-AMC	Biochemical Assay Reagents	Others
Gly-Phe-AFC is a fluorescent substrate, which is a peptide sequence composed of glycine and phenylalanine, linked to the fluorescent group AFC .

HY-P3752

Gly-Ala-Tyr	Peptides	Others
Gly-Ala-Tyr is a tripeptide composed of L-glycine, alanine and L-tyrosine joined in sequence by peptide linkages. Ala-Gly-Tyr is functionally related to L-alanine, glycine and L-tyrosine.

HY-P3993A

*(Gly14)-Humanin (human) (acetate)* 14-Glycine-Humanin (human) (acetate)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-W010276

Gly-Sar Glycylsarcosine	Amino Acid Derivatives	Others
Gly-Sar is a Glycine (HY-Y0966) derivative .

HY-P0148A

Gly6 hydrochloride HexaGlycine hydrochloride	Peptides	Others
Gly6 hydrochloride (Hexaglycine hydrochloride) is a linear glycine oligopeptide with six glycines .

HY-W141918

Gly-Leu-Tyr	Amino Acid Derivatives	Others
Gly-Leu-Tyr is a Glycine (HY-Y0966) derivative .

HY-P3993

*(Gly14)-Humanin (human)* 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

HY-P3888

Gly-Leu-Met-NH2	Neurokinin Receptor	Neurological Disease
Gly-Leu-Met-NH2 is a C-terminal tripeptide of Substance P (Substance P (HY-P0201)). Substance P is a neuropeptide .

HY-W016887R

Glycyl-L-proline (Standard) H-Gly-Pro-OH (Standard)	Endogenous Metabolite	Metabolic Disease
H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

HY-P3845

*(Gly22)-Amyloid β-Protein (1-42)*	Amyloid-β	Neurological Disease
(Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation .

HY-W016887

Glycyl-L-proline H-Gly-Pro-OH	Endogenous Metabolite	Metabolic Disease
Glycyl-L-proline (H-Gly-Pro-OH) is an end product of collagen metabolism that is further cleaved by prolidase.

HY-P0074A

GPRP acetate 1 Publications Verification Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate	Integrin	Cardiovascular Disease
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P2660

Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide GD4K-na	Enteropeptidase	Others
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (K_m: 0.16 mM) .

HY-W141916

Pentaglycine TetraGlycylGlycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Peptides	Infection
Pentaglycine (Tetraglycylglycine) is a bridge containing five glycine molecules. Pentaglycine can form highly cross-linked peptidoglycan. Glucose reduced expression of pentaglycine. Pentaglycine is cleaved by lysostaphin, and occurs in the cell envelope of staphylococci .

HY-P0074

GPRP 1 Publications Verification Gly-Pro-Arg-Pro; Pefa 6003	Integrin	Cardiovascular Disease
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-113736

Glycyllysine	Amino Acid Derivatives	Others
Glycyllysine is a polypeptide that can be used in the synthesis of antibodies and amino acid type gemini surfactants. Glycyllysine has potential applications in modifying plasmid/gemini/lipid (P/G/L) nanoparticles transport carriers .

HY-P5747

Glycocin F	Peptides	Others
Glycocin F is a antimicrobial peptide with activity against L. plantarum .

HY-P1843

Glycoprotein (276-286)	Arenavirus	Infection
Glycoprotein (276-286) is a Db-restricted peptide derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), corresponds to amino acids 276-286[1].

HY-P4275

Glycylglycinamide	Peptides	Others
Glycylglycinamide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1315

Papain inhibitor GlycylGlycyl-L-tyrosyl-L-arginine	Cathepsin	Others
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a K_i of 9 μM at pH 6.2 .

HY-P4230

Glycylalanylglycine	Peptides	Others
Glycylalanylglycine is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4263

Glycylglycylalanine	Peptides	Others
Glycylglycylalanine is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4283

Glycylhistidylglycine	Peptides	Others
Glycylhistidylglycine is composed of two glycines and one histidine, which can detect and remove the concentration of Cu2+ ions in wastewater by forming a tripeptide complex with copper and nickel ions.

HY-P4269

Glycylglycylcysteine	Peptides	Cardiovascular Disease
Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a K_i of 0.99 μM and a IC₅₀ of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin .

HY-P5296

*Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans*	Fluorescent Dye	Others
Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans is a fluorophore Dabsyl-labeled peptide. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans can be used to test the peptidase activity of the LasA protease of Pseudomonas aeruginosa. Dabsyl-Leu-Gly-Gly-Gly-Ala-Edans has enzyme specificity and has application value .

HY-P4192

*Fomc-Gly-Gly-Phe-Gly-OH*	ADC Linker	Cancer
Fomc-Gly-Gly-Phe-Gly-OH (compound D5) can be used as an intermediate in the synthesis of ADC dual-drug-linker. Fomc-Gly-Gly-Phe-Gly-OH synthetic intermediate GGFGE further forms an important ADC dual-drug link assembly unit .

HY-P3827

Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly	Peptides	Inflammation/Immunology
Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a13-mer synthetic peptide containing seven amino acids homologous to SV40 T antigen. Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is capable of inducing nuclear transport .

HY-P4294

*H-Gly-Pro-Gly-OH*	Amino Acid Derivatives	Others
H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)_n .

HY-P2718

*Z-Gly-Pro-Gly-Gly-Pro-Ala-OH*	Biochemical Assay Reagents	Others
Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is a collagenase substrate that induces planulae to settle .

HY-P5355

*Z-Gly-Gly-Arg-AFC*	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AFC is a biological active peptide. (Plasminogen Activator Acrosine Substrate, fluorescent Z-Gly-Gly-Arg-AFC)

HY-P4530

*D-Ala-Gly-Gly-OH*	Peptides	Others
D-Ala-Gly-Gly-OH is a peptide substrate. DppA has a poor efficiency on peptide substrates D-Ala-Gly-Gly-OH .

HY-P4287

*H-Gly-Lys-Gly-OH*	Amino Acid Derivatives	Others
H-Gly-Lys-Gly-OH is a tripeptide containing glycine and lysine. H-Gly-Lys-Gly-OH can be used for the synthesis of casein and soybean protein .

Cat. No.	Product Name

HY-K1021

Tris-Glycine Powder (1 L of 1×)
MCE Tris-Glycine Powder (1 L of 1×) consists of Tris and Glycine, and is widely used as an electrophoresis buffer for Native-PAGE.

HY-K0214

Protein G Agarose 2 Publications Verification
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

HY-K0230

Protein A/G Agarose 10+ Cited Publications
MCE Protein A/G Agarose is an affinity chromatography medium for separation and purification of immunoglobulins.

HY-K0204

Protein G Magnetic Beads 30+ Cited Publications
Protein G Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0202

Protein A/G Magnetic Beads Maximum Cited Publications 733 Publications Verification
MCE Protein A/G Magnetic Beads provide a fast and convenient method for Immunoprecipitation, Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K1032

6× DNA Loading Buffer with SDS
MCE 6× DNA Loading Buffer with SDS is a modified 6-fold buffer and mainly consists of glycerin, EDTA, SDS, Orange G and Xylene Cyanol FF.

HY-K0202K

IP/Co-IP Kit (Protein A/G Magnetic Beads)
MCE IP/Co-IP Kit (Protein A/G Magnetic Beads) can be used for protein purification, IP, Co-IP of target proteins or their protein complexes.

HY-K0243

Protein G Plus Magnetic Agarose Beads 2 Publications Verification
MCE Protein G Plus Magnetic Agarose Beads can be used for the detection and purification of IgG from serum, ascites fluid, cell culture supernatant and other antibody samples.

HY-K1056

G418 Selective Antibiotic, Sterile 3 Publications Verification
MCE G418 Selective Antibiotic, Sterile is an aminoglycoside antibiotic produced by Micromonospora rhodorangea. It acts by binding to the 80S subunit of the bacterial ribosome, thus inhibiting protein synthesis in both prokaryotic and eukaryotic cells.

HY-K1103

Coomassie Blue Fast Staining Solution (No Heating, 10×)
MCE Coomassie Blue Fast Staining Solution (No Heating, 10×) uses Coomassie Brilliant Blue G250 as the dye. It can be used for rapid, sensitive staining of protein gels in SDS-PAGE or Native-PAGE without contamination, or for detecting residual proteins on PAGE gels after Western Blot transfer.

Cat. No.	Product Name	Target	Research Area

HY-P99142

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5) 1 Publications Verification	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse Ly-6G/Ly-6C Antibody is an anti-mouse Ly-6G/Ly-6C IgG2b antibody inhibitor.

HY-P990199

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)	Inhibitory Antibodies	Others
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse Ly6G/Ly6C.

HY-P990020

Eglatoprutug	c-Kit	Others
Eglatoprutug is an humanized immunoglobulin *G1-kappa, anti-c-Kit* monoclonal antibody .

HY-P990860

Anti-CD40 Antibody (G28.5)	Inhibitory Antibodies	Others
Anti-CD40 Antibody (G28.5) is a kind of mouse IgG1, κ chimeric antibody, targeting to human CD40. The recommend isotype control of Anti-CD40 Antibody (G28.5): Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-P990045

Lixudebart	Inhibitory Antibodies	Cancer
Lixudebart is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody .

HY-P990039

Falbikitug	Inhibitory Antibodies	Cancer
Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic .

HY-P991184

Anti-LY6G6D Antibody (1G4)	Inhibitory Antibodies	Cancer
Anti-LY6G6D Antibody (1G4) is a humanized IgG1 monoclonal antibody that targets *LY6G6D*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990716

Sabestomig	PD-1/PD-L1	Inflammation/Immunology
Sabestomig is an anti-PDCD1/HAVCR2 Ig(G1-κ G1-λ2) monoclonal antibody .

HY-P990633

NC-318 (5G-12) 5G-12	Inhibitory Antibodies	Inflammation/Immunology
NC-318 (5G-12) is a human-derived antibody expressed by CHO, targeting Siglec-15/CD33L3. NC-318 (5G-12) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.98 kDa. The isotype control for NC-318 (5G-12) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991003

Ingitamig	TNF Receptor	Inflammation/Immunology
HY-P991003 is an TNFRSF17/KLRK1-targeting (G1_L-κ)_(G1-scFvkh_L-κ) type bispecific antibody .

HY-P990753

Omoprubart	Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human IgG2-G4 κ monoclonal antibody .

HY-P990089

Patecibart Getagozumab; GMA-301	Endothelin Receptor	Cardiovascular Disease
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist .

HY-P990683

Satumomab	Inhibitory Antibodies	Inflammation/Immunology
Satumomab is an anti-TAG-72 IgG4-G2a κ monoclonal antibody .

HY-P990047

Maridebart AMG133 antibody	GLP Receptor	Metabolic Disease
Maridebart is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody .

HY-P990048

Muzastotug	CTLA-4	Cancer
Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .

HY-P990074

Enlonstobart	PD-1/PD-L1	Inflammation/Immunology
Enlonstobart is a human immunoglobulin G4-kappa, anti-PDCD1 monoclonal antibody. Enlonstobart is an immunostimulant and antineoplastic .

HY-P990800

Anti-Mouse IL-4 Antibody (BVD6-24G2)	Interleukin Related	Others
Anti-Mouse IL-4 Antibody (BVD6-24G2) is a kind of rat IgG1 kappa in vivo mouse antibody, targeting to IL-4. The recommend isotype control of Anti-Mouse IL-4 Antibody (BVD6-24G2): Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-P991033

Tovecimig	VEGFR	Inflammation/Immunology
HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody .

HY-P990080

Sovipostobart	CTLA-4	Cancer
Sovipostobart is an immunoglobulin G1-kappa, anti-CTLA-4 human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .

HY-P990095

Vonsetamig	CD3 TNF Receptor	Inflammation/Immunology Cancer
Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E bispecific antibody. Vonsetamig is an antineoplastic .

HY-P99686

Larcaviximab c4G7-N	Filovirus	Infection
Larcaviximab (c4G7-N) is an IgG1 kappa anti-Ebola virus glycoprotein chimeric monoclonal antibody .

HY-P99606

Cirevetmab ZTS-00521426	TGF-beta/Smad	Inflammation/Immunology
Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 caninized monoclonal antibody. Cirevetmab is an immunomodulator .

HY-P990118

Anti-Mouse Ly6G Antibody (1A8)	Inhibitory Antibodies	Others
Anti-Mouse Ly6G Antibody (1A8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse Ly6G.

HY-P990068

Perenostobart SRF617	NTPDase	Cancer
Perenostobart is a human immunoglobulin G4-kappa, anti-ENTPD1/CD39 monoclonal antibody. Perenostobart is an immunostimulant and antineoplastic .

HY-P990081

Oloctinebart	Inhibitory Antibodies	Neurological Disease
Oloctinebart is a humanized immunoglobulin G4-kappa, anti-LGALS3 monoclonal antibody. Oloctinebart is used for reduction of amyloid beta oligomers formation .

HY-P990148

Anti-Mouse VEGF-A Antibody (2G11-2A05)	Inhibitory Antibodies	Others
Anti-Mouse VEGF-A Antibody (2G11-2A05) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse VEGF-A.

HY-P990947

Tilatamig	EGFR	Inflammation/Immunology
HY-P990947 is an EGFR/MET-targeting Ig(G1 -κ_G1 -λ2) type human antibody .

HY-P990169

Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12)	PD-1/PD-L1	Others
Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse/human phosphorylated PD-1/CD279. Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407.6G12) can be used in WB and FC experiments in the context of human and mouse.

HY-P990092

Rolistobart	Transmembrane Glycoprotein	Cancer
Rolistobart is a humanized immunoglobulin G4-kappa, anti-LILRB4/CD85k monoclonal antibody. Rolistobart is an immunostimulant and antineoplastic .

HY-P99879

Efbemalenograstim alfa Benegrastim; Bineuta; F 627	STAT	Inflammation/Immunology
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .

HY-P990981

Clesitamig	Inhibitory Antibodies	Inflammation/Immunology
HY-P990981 is an DLL3-targeting (V-κ-G4CH1-G1h-H-γ1_L-κ)_Lκ)]_(H-γ1_L-κ) type humanized antibody .

HY-P991248

TTX-080	Inhibitory Antibodies	Cancer
TTX-080 is a humanized monoclonal antagonistic antibody targeting human leukocyte antigen G (HLA-G). TTX-080 exerts anti-tumor activity by relieving HLA-G-mediated immune suppression. TTX-080 is promising for research of solid tumors such as metastatic colorectal cancer (mCRC) and head and neck squamous cell carcinoma (mHNSCC) .

HY-P991464

IBI37G5	TNF Receptor	Cancer
IBI37G5 is a human monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. IBI37G5 has anti-tumor activity in MC38 and B16F10 mouse tumor models. IBI37G5 can be used in the study of cancer immunity .

HY-P990237

Anti-Mouse ICOS Antibody (7E.17G9)	Inhibitory Antibodies	Others
Anti-Mouse ICOS Antibody (7E.17G9) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse ICOS.

HY-P990698

Umizortamig	PD-1/PD-L1 EGFR	Inflammation/Immunology
Umizortamig is an anti-CD3E/EGFR/TNFRSF9/PD-L1/CD3G monoclonal antibody .

HY-P990324

Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) 3F6-9G5	Adenosine Receptor	Inflammation/Immunology
Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) is a humanized antibody expressed in CHO cells, targeting AA2AR/Adenosine A2aR. Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 146.66 kDa. The isotype control for Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990079

Renvistobart BMS-986207; ONO-4686	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P990220

Anti-Mouse IL-18 Antibody (YIGIF74-1G7)	Inhibitory Antibodies	Others
Anti-Mouse IL-18 Antibody (YIGIF74-1G7) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse IL-18.

HY-P990217

Anti-Mouse IL-23 p19 Antibody (G23-8)	Interleukin Related	Others
Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-23 p19.

HY-P991139

Futermestotug	CTLA-4	Cancer
Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors .

HY-P990275

Anti-Mouse CD326/EpCAM Antibody (G8.8)	Inhibitory Antibodies	Others
Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD326/EpCAM.

HY-P99510

Zansecimab LY-3127804	Tie	Inflammation/Immunology Cancer
Zansecimab (LY-3127804) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2 (Ang 2). Zansecimab has potential applications in angiogenesis and immune regulation .

HY-P9922

Olaratumab IMC-3G3; LY3012207	PDGFR	Cancer
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity .

HY-P991152

Oturkibart	Interleukin Related	Inflammation/Immunology
Oturkibart is a humanized immunoglobulin G4-κ monoclonal antibody targeting the human interleukin 4 receptor (IL4R). Oturkibart is promising for research of inflammatory diseases, such as asthma and atopic dermatitis .

HY-P990384

Anti-CSF3R/G-CSFR Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-CSF3R/G-CSFR Antibody is a CHO-expressed human antibody that targets *CSF3R/G-CSFR*. Anti-CSF3R/G-CSFR Antibody contains huIgG4SP heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CSF3R/G-CSFR Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P99367

Ifinatamab	CD3	Inflammation/Immunology Cancer
Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur .

HY-P99698

Lesabelimab LDP	PD-1/PD-L1	Inflammation/Immunology Cancer
Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor .

HY-P991135

Enzelkitug	CCR	Cancer
Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .

HY-P991137

Exerenibart	Ser/Thr Protease	Metabolic Disease
Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency .

HY-P990953

Zubotamig Gen1047	CD3	Inflammation/Immunology
HY-P990953 is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody .

Cat. No.	Product Name		Classification

HY-140309

Gly-Gly-Gly-PEG4-DBCO		ADC Synthesis DBCO
Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-157275

Gly-Gly-Gly-PEG2-azide		ADC Synthesis Azide
Gly-Gly-Gly-PEG2-azide is an ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-141190

Gly-Gly-Gly-PEG3-TCO		TCO ADC Synthesis
Gly-Gly-Gly-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-145066

Gly-Gly-Gly-PEG4-azide		ADC Synthesis Azide
Gly-Gly-Gly-PEG4-azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Gly-Gly-Gly-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151777

*N3-Gly-Gly-Gly-Gly-Gly-OH*		Azide
N3-Gly-Gly-Gly-Gly-Gly-OH is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151859

*N3-Gly-Gly-OH*		Azide
N3-Gly-Gly-OH is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-157407

*Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan*		Alkynes
Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate for ADC (ADC Cytotoxin: Exatecan) .

HY-141284

Gly-Gly-Gly-PEG4-methyltetrazine		ADC Synthesis Tetrazine
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140080

Gly-PEG3-endo-BCN		BCN PROTAC Synthesis
Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-151746

*N3-Gly-Gly-Gly-OH*		Azide
N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved . N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151859A

*N3-Gly-Gly-OH (DCHA)*		Azide
N3-Gly-Gly-OH (DCHA) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-140081

*Boc-gly-PEG3-endo-BCN*		BCN PROTAC Synthesis ADC Synthesis
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Boc-gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-131455A

*Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA*		Azide
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151658

*H-L-Lys(N3-Gly)-OH*		Azide
H-L-Lys(N3-Gly)-OH is a click chemistry containing an azide group, a lysine derivative. H-L-Lys(N3-Gly)-OH can be incorporated into proteins for click modifications . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151658A

*H-L-Lys(N3-Gly)-OH hydrochloride*		Azide
H-L-Lys(N3-Gly)-OH hydrochloride is a click chemistry containing an azide group, a lysine derivative. H-L-Lys(N3-Gly)-OH hydrochloride can be incorporated into proteins for click modifications . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]		Azide
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-151782

*H-(Gly)3-Lys(N3)-OH*		Azide
The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151828

*N3-Gly-Aeg(Fmoc)-OH*		Azide
N3-Gly-Aeg(Fmoc)-OH is a click chemistry reagent containing an azide group. PNA building-block that can be further modified using Click-chemistry . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151659

*Fmoc-L-Lys(N3-Gly)-OH*		Azide
Fmoc-L-Lys(N3-Gly)-OH is a click chemistry reagent containing a lysine-containing azidoacetyl group building-block for SPPS and can be used for various biochemical studies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151782A

*H-(Gly)3-Lys(N3)-OH hydrochloride*		Azide
H-(Gly)3-Lys(N3)-OH (hydrochloride) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-134811

KRAS G12D inhibitor 1		Alkynes
KRAS G12D inhibitor 1 (example 243) is a KRAS G12D inhibitor, with an IC₅₀ of 0.8 nM for KRAS G12D-mediated ERK phosphorylation . KRAS G12D inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159652

KRAS inhibitor-31		Alkynes
KRAS inhibitor-31 (compound 33) is a KRAS inhibitor, with K_D (SPR) values of 0.019 nM, 0.019 nM and 0.096 nM for KRas G12D, KRas G12C and KRas G12V, respectively .

HY-158701

KRAS G12D inhibitor 23		Alkynes
KRAS G12D inhibitor 23 (compound 46-3) is a potent inhibitor of KRAS G12D, with the IC₅₀ of 0.007 μM. KRAS G12D inhibitor 23 plays an important role in cancer research .

HY-158007

(RS)-G12Di-1		Alkynes
(RS)-G12Di-1 is a selective, covalent inhibitor of *K-Ras-G12D* .

HY-115880

KRAS G12D inhibitor 3		Alkynes
KRAS G12D inhibitor 3 is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 has antitumor effects (WO2022002102A1; compound 146) . KRAS G12D inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115880A

KRAS G12D inhibitor 3 TFA		Alkynes
KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146) . KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159474

KRAS inhibitor-24		Azide
KRAS inhibitor-24 (compound 115c) is a pyridopyrimidine KRAS inhibitor, with an IC₅₀ of < 100 nM for KRas G12V, KRas WT and KRas G12R .

HY-159475

KRAS inhibitor-25		Azide
KRAS inhibitor-25 (compound 151a) is a pyridopyrimidine KRAS inhibitor, with an IC₅₀ of < 100 nM against KRas G12V, KRas WT and KRas G12R .

HY-134813

MRTX1133 20+ Cited Publications		Alkynes
MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated K_D against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations .

HY-147595

KRAS G12D inhibitor 15		Alkynes
KRAS G12D inhibitor 15 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 15 has the potential for the research of various diseases or disorders, such as cancer or cancer metastasis (extracted from patent WO2022042630A1, compound 243) . KRAS G12D inhibitor 15 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162446

pan-KRAS-IN-13		Alkynes
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-153627

GK13S		Alkynes
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W739389

p-Nitrophenyl 2-azido-2-deoxy-α-D-galactopyranoside		Azide
Azocarmine G (Acid Red 101; Rosinduline) is a biochemical assay reagent.

HY-159519

EGFR/HER2-IN-16		Azide
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

HY-128522

ARS-1323-alkyne		Alkynes
ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy, providing tool support for the development of combination treatment strategies .

HY-155541

Antitumor agent-110		Alkynes
Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good permeability properties. Antitumor agent-110 arrests cell cycel at G2/M phase, and induces apoptosis . Antitumor agent-110 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-145962

MRTX-EX185		Alkynes
MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and *KRAS(G12D), with an IC₅₀* of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS . MRTX-EX185 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-145962A

MRTX-EX185 formic		Alkynes
MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and *KRAS(G12D), with an IC₅₀* of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS . MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-173637

AZD0022		Alkynes
AZD0022 is a selective and orally active KRAS ^G12D inhibitor. AZD0022 inhibits KRAS pathway suppression in the GP2D xenograft model .

HY-134654

MRTX849 analog 24		Alkynes
MRTX849 analog 24 is an alkyne-containing click probe analogue of KRAS G12C inhibitor MRTX849, which is used to research MRTX849 function .

HY-159476

KRAS inhibitor-26		Azide
KRAS inhibitor-26 (compound 194a) is a potent KRAS G12V inhibitor (IC₅₀: ≤100 nM). KRAS inhibitor-26 can be used for cancer research .

HY-159473

K-Ras-IN-3		Alkynes
K-Ras-IN-3 (compound 3) is a potent GDP-KRAS G12V inhibitor with an IC₅₀ value of 0.371 nM. K-Ras-IN-3 has the potential for the research of cancer .

HY-W010642

Pent-4-yn-1-ol 4-Pentyn-1-ol		Alkynes
Pent-4-yn-1-ol is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g. RD-23 (HY-168867)) .

HY-163488

KRASG12D-IN-4		Alkynes
KRASG12D-IN-4 (example 38) is a KRas ^G12D inhibitor with an IC₅₀ of 3.3 nM. KRASG12D-IN-4 inhibits proliferation of pancreatic cancer ASPC-1 cells with an IC₅₀ of 12 nM .

HY-B1029

Danazol 4 Publications Verification		Alkynes
Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC₅₀ of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway .

HY-157029S

KRASG12D-IN-1		Alkynes
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-157031S

KRASG12D-IN-2		Alkynes
KRASG12D-IN-2 (compound 28) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

HY-147858

PROTAC EGFR degrader 7		Alkynes
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFR ^L858R/T790M degrader, with a DC₅₀ of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC₅₀ of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research . PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159511

Hedgehog IN-7		Azide
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

Cat. No.	Product Name		Classification

HY-N0593A

Deoxycholic acid sodium salt Maximum Cited Publications 15 Publications Verification Sodium deoxycholate		Emulsifiers
Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-150751C

ODN TTAGGG sodium 1 Publications Verification ODN A151 sodium		CpG ODNs
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-150751

ODN TTAGGG 1 Publications Verification ODN A151		CpG ODNs
ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-150747A

ODN 6016 sodium		CpG ODNs
ODN 6016 sodium is a CpG-A oligonucleotides. ODN 6016 sodium can induce IFN-α production, and can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-150748A

ODN D-SL01 sodium		CpG ODNs
ODN D-SL01 sodium, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN D-SL01 sodium has strong immunostimulatory activity in a variety of vertebrate species and has anticancer activity. ODN D-SL01 sequence: 5'- T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3' .

HY-150745A

ODN 24987 sodium		CpG ODNs
ODN 24987 sodium is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 sodium can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’ .

HY-W441005

*Amino-Gly-Gly-DSPE hydrochloride*		Phospholipids
Amino-Gly-Gly-DSPE (hydrochloride) is a specially modified phospholipid that has been used to synthesize liposomes. The terminal amine is reactive with an NHS ester compound or carboxylic acid molecule in the presence of activator, such as HATU or EDC.

HY-150747

ODN 6016		CpG ODNs
ODN 6016 is a CpG-A oligonucleotides. ODN 6016 can induce IFN-α production, can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-150748

ODN D-SL01		CpG ODNs
ODN D-SL01, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN D-SL01 has strong immunostimulatory activity in a variety of vertebrate species and has anticancer activity. ODN D-SL01 sequence: 5'- T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3' .

HY-150745

ODN 24987		CpG ODNs
ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’ .

HY-W013706

Inosine-5'-triphosphate trisodium salt		Nucleotides and their Analogs
Inosine-5'-triphosphate trisodium salt is a nucleotide analogue that acts on multiple G proteins and is widely used in G protein-related research. It can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Its mechanism of action is to interact with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. In the research field, it is mainly used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. For example, in HL-60 leukemia cells, its impact on G protein-mediated signal transduction can be studied .

HY-152229

G0-C14		Cationic Lipids
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .

HY-150746

ODN 24991		CpG ODNs
ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR3, TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-150746A

ODN 24991 sodium		CpG ODNs
ODN 24991 sodium, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR3, TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 sodium disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-147339

M7G(3'-OMe-5')pppA(2'-OMe)		Cap Analogs
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.

HY-158772

m7G(5')ppp(5')(2'OMeA)pU ammonium		Cap Analogs
m7G(5')ppp(5')(2'OMeA)pU ammonium is a cap analog that can be used for in vitro transcription of mRNA.

HY-R03469

mmu-miR-669g mimic		MicroRNAs miRNA mimics
mmu-miR-669g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03178

mmu-miR-466g mimic		MicroRNAs miRNA mimics
mmu-miR-466g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03071

mmu-miR-3473g mimic		MicroRNAs miRNA mimics
mmu-miR-3473g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RS06217

HLA-G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
HLA-G Human Pre-designed siRNA Set A contains three designed siRNAs for HLA-G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-R00850

hsa-miR-378g mimic		MicroRNAs miRNA mimics
hsa-miR-378g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R04366

rno-miR-344g mimic		MicroRNAs miRNA mimics
rno-miR-344g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-148504

5'-ODMT cEt G Phosphoramidite (Amidite)		Nucleoside Phosphoramidites
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity .

HY-R03205

mmu-miR-467g mimic		MicroRNAs miRNA mimics
mmu-miR-467g mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-160580

G1-OC2-K3-E10		Cationic Lipids
G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs) .

HY-139100B

m7G(5')ppp(5')A diammonium m7GpppA diammonium; N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium		Cap Analogs Cap Analogs
m7G(5')ppp(5')A (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription .

HY-RS29087

Idh3g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Idh3g Rat Pre-designed siRNA Set A contains three designed siRNAs for Idh3g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06761

IL36G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL36G Human Pre-designed siRNA Set A contains three designed siRNAs for IL36G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27103

Sema4g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sema4g Rat Pre-designed siRNA Set A contains three designed siRNAs for Sema4g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21912

Polr2g Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Polr2g Mouse Pre-designed siRNA Set A contains three designed siRNAs for Polr2g gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02244

CD3G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD3G Human Pre-designed siRNA Set A contains three designed siRNAs for CD3G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00840

APOBEC3G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APOBEC3G Human Pre-designed siRNA Set A contains three designed siRNAs for APOBEC3G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10236

PDE6G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PDE6G Human Pre-designed siRNA Set A contains three designed siRNAs for PDE6G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29412

Ush1g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ush1g Rat Pre-designed siRNA Set A contains three designed siRNAs for Ush1g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12555

SCNN1G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SCNN1G Human Pre-designed siRNA Set A contains three designed siRNAs for SCNN1G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06535

IDH3G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IDH3G Human Pre-designed siRNA Set A contains three designed siRNAs for IDH3G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10965

PPM1G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PPM1G Human Pre-designed siRNA Set A contains three designed siRNAs for PPM1G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01861

CAMK2G Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
CAMK2G Rat Pre-designed siRNA Set A contains three designed siRNAs for CAMK2G gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10860

POLR3G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POLR3G Human Pre-designed siRNA Set A contains three designed siRNAs for POLR3G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22898

Ush1g Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ush1g Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ush1g gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05195

G6PR Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
G6PR Human Pre-designed siRNA Set A contains three designed siRNAs for G6PR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12662

SEMA4G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SEMA4G Human Pre-designed siRNA Set A contains three designed siRNAs for SEMA4G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05231

GADD45G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GADD45G Human Pre-designed siRNA Set A contains three designed siRNAs for GADD45G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21927

Sema3g Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sema3g Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sema3g gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20530

Camk1g Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Camk1g Mouse Pre-designed siRNA Set A contains three designed siRNAs for Camk1g gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28429

Polr2g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Polr2g Rat Pre-designed siRNA Set A contains three designed siRNAs for Polr2g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25785

C8g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
C8g Rat Pre-designed siRNA Set A contains three designed siRNAs for C8g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22997

G6pd Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
G6pd Rat Pre-designed siRNA Set A contains three designed siRNAs for G6pd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27434

Eif3g Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Eif3g Rat Pre-designed siRNA Set A contains three designed siRNAs for Eif3g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02796

CLEC4G Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CLEC4G Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC4G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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