PAMAM Dendrimer G0.0 amine (20% in methanol)

Name: PAMAM Dendrimer G0.0 amine (20% in methanol)
Brand: MedChemExpress
SKU: HY-W157376
Rating: 4.5 (1 reviews)

Cat. No.: HY-W157376: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC₅₀ = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC₅₀ = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems.

For research use only. We do not sell to patients.

PAMAM Dendrimer G0.0 amine (20% in methanol) Chemical Structure

CAS No. : 155773-72-1

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

516.68

Formula

C₂₂H₄₈N₁₀O₄

CAS No.

155773-72-1

Appearance

Liquid (Density: 1.162±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(CCN(CCN(CCC(NCCN)=O)CCC(NCCN)=O)CCC(NCCN)=O)NCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (193.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9354 mL	9.6772 mL	19.3543 mL
5 mM	0.3871 mL	1.9354 mL	3.8709 mL
10 mM	0.1935 mL	0.9677 mL	1.9354 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Heiden TC, et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol Appl Pharmacol. 2007 Nov 15;225(1):70-9. [Content Brief]

[2]. Förstner P, et al. Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules. 2014 Jul 14;15(7):2461-74. [Content Brief]

[3]. Sohail I, et al. Polyamidoamine (PAMAM) dendrimers synthesis, characterization and adsorptive removal of nickel ions from aqueous solution[J]. Journal of Materials Research and Technology, 2020, 9(1): 498-506.

[4]. Xiao Y, et al. Surface characterization, modification chemistry, and separation performance of polyimide and polyamidoamine dendrimer composite films. Langmuir. 2004 Sep 14;20(19):8230-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9354 mL	9.6772 mL	19.3543 mL	48.3858 mL
	5 mM	0.3871 mL	1.9354 mL	3.8709 mL	9.6772 mL
	10 mM	0.1935 mL	0.9677 mL	1.9354 mL	4.8386 mL
	15 mM	0.1290 mL	0.6451 mL	1.2903 mL	3.2257 mL
	20 mM	0.0968 mL	0.4839 mL	0.9677 mL	2.4193 mL
	25 mM	0.0774 mL	0.3871 mL	0.7742 mL	1.9354 mL
	30 mM	0.0645 mL	0.3226 mL	0.6451 mL	1.6129 mL
	40 mM	0.0484 mL	0.2419 mL	0.4839 mL	1.2096 mL
	50 mM	0.0387 mL	0.1935 mL	0.3871 mL	0.9677 mL
	60 mM	0.0323 mL	0.1613 mL	0.3226 mL	0.8064 mL
	80 mM	0.0242 mL	0.1210 mL	0.2419 mL	0.6048 mL
	100 mM	0.0194 mL	0.0968 mL	0.1935 mL	0.4839 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.