2. Neuronal Signaling
  3. Amyloid-β
  4. Semax acetate

Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia.

For research use only. We do not sell to patients.

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Semax acetate Chemical Structure

Semax acetate Chemical Structure

CAS No. : 2828433-33-4

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Based on 1 publication(s) in Google Scholar

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Semax acetate Related Antibodies

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Description

Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].

In Vitro

Semax (25-100 μM, 48 h) acetate can reduce the levels of Aβ oligomers[1].
Semax (100 nM) acetate can increase the survival rate of cholinergic neurons in the basal forebrain and stimulate the activity of choline acetyltransferase in cultured basal forebrain tissue ex vivo[2].
Semax (10 μM, 0-4 h) acetate can increase the levels of BDNF and NGF in glial cells derived from the basal forebrain of newborn rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Semax acetate Related Antibodies

Real Time qPCR[3]

Cell Line: Glial cell cultures from rat basal forebrain
Concentration: 10 μM
Incubation Time: 0.5, 1, 2, 3, 4, 8, 16 and 24 h
Result: Increased the mRNA levels of BDNF and NGF.
In Vivo

Semax (100 μg/kg; intraperitoneal injection; single dose) acetate has an ameliorating effect in a rat model of focal cerebral ischemia[4].
Semax (0.15 mg/kg; intraperitoneal injection; single dose) acetate can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia (pMCAO) rats[4]
Dosage: 100 μg/kg
Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
Result: Affected the expression of genes related to the immune system. At 3 hours after pMCAO, it influenced the expression of genes regulating the activity of immune cells such as macrophages, neutrophils, and lymphocytes. At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response.
Affected the expression of genes related to the vascular system. At 3 hours after pMCAO, it influenced genes involved in vasculogenesis, hematopoiesis, and endothelial cell migration. At 24 hours after pMCAO, it affected the development of endothelial tissue, the migration of smooth muscle cells, and the activation of blood cells.
Molecular Weight

873.97

Formula

C39H55N9O12S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro
Sequence Shortening

MEHFPGP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (171.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1442 mL 5.7210 mL 11.4420 mL
5 mM 0.2288 mL 1.1442 mL 2.2884 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1442 mL 5.7210 mL 11.4420 mL 28.6051 mL
5 mM 0.2288 mL 1.1442 mL 2.2884 mL 5.7210 mL
10 mM 0.1144 mL 0.5721 mL 1.1442 mL 2.8605 mL
15 mM 0.0763 mL 0.3814 mL 0.7628 mL 1.9070 mL
20 mM 0.0572 mL 0.2861 mL 0.5721 mL 1.4303 mL
25 mM 0.0458 mL 0.2288 mL 0.4577 mL 1.1442 mL
30 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9535 mL
40 mM 0.0286 mL 0.1430 mL 0.2861 mL 0.7151 mL
50 mM 0.0229 mL 0.1144 mL 0.2288 mL 0.5721 mL
60 mM 0.0191 mL 0.0954 mL 0.1907 mL 0.4768 mL
80 mM 0.0143 mL 0.0715 mL 0.1430 mL 0.3576 mL
100 mM 0.0114 mL 0.0572 mL 0.1144 mL 0.2861 mL
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Semax acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semax2828433-33-4Amyloid-ββ-amyloid peptideAβAbetaIschemiaBDNFastrocytesnootropicneuroprotectiveischemia? modelAD modelneuronsInhibitorinhibitorinhibit

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