2. Neuronal Signaling
  3. Amyloid-β
  4. Semax

Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia.

For research use only. We do not sell to patients.

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Semax Chemical Structure

Semax Chemical Structure

CAS No. : 80714-61-0

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Based on 1 publication(s) in Google Scholar

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Semax Related Antibodies

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Description

Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].

In Vitro

Semax (25-100 μM, 48 h) can reduce the levels of Aβ oligomers[1].
Semax (100 nM) can increase the survival rate of cholinergic neurons in the basal forebrain and stimulate the activity of choline acetyltransferase in cultured basal forebrain tissue ex vivo[2].
Semax (10 μM, 0-4 h) can increase the levels of BDNF and NGF in glial cells derived from the basal forebrain of newborn rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Semax Related Antibodies

Real Time qPCR[3]

Cell Line: Glial cells derived from the basal forebrain of newborn rats
Concentration: 10 μM
Incubation Time: 0, 0.5, 1, 2, 3, 4, 8, 16 and 24 h
Result: Increased the mRNA levels of the BDNF and NGF.
In Vivo

Semax (100 μg/kg; intraperitoneal injection; single dose) has an ameliorating effect in a rat model of focal cerebral ischemia[4].
Semax (0.15 mg/kg; intraperitoneal injection; single dose) can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia (pMCAO) rats[4]
Dosage: 100 μg/kg
Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
Result: Affected the expression of genes related to the immune system. At 3 hours after pMCAO, it influenced the expression of genes regulating the activity of immune cells such as macrophages, neutrophils, and lymphocytes. At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response.
Affected the expression of genes related to the vascular system. At 3 hours after pMCAO, it influenced genes involved in vasculogenesis, hematopoiesis, and endothelial cell migration. At 24 hours after pMCAO, it affected the development of endothelial tissue, the migration of smooth muscle cells, and the activation of blood cells.
Molecular Weight

813.92

Formula

C37H51N9O10S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro
Sequence Shortening

MEHFPGP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (122.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2286 mL 6.1431 mL 12.2862 mL
5 mM 0.2457 mL 1.2286 mL 2.4572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2286 mL 6.1431 mL 12.2862 mL 30.7156 mL
5 mM 0.2457 mL 1.2286 mL 2.4572 mL 6.1431 mL
10 mM 0.1229 mL 0.6143 mL 1.2286 mL 3.0716 mL
15 mM 0.0819 mL 0.4095 mL 0.8191 mL 2.0477 mL
20 mM 0.0614 mL 0.3072 mL 0.6143 mL 1.5358 mL
25 mM 0.0491 mL 0.2457 mL 0.4914 mL 1.2286 mL
30 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0239 mL
40 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7679 mL
50 mM 0.0246 mL 0.1229 mL 0.2457 mL 0.6143 mL
60 mM 0.0205 mL 0.1024 mL 0.2048 mL 0.5119 mL
80 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3839 mL
100 mM 0.0123 mL 0.0614 mL 0.1229 mL 0.3072 mL
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Semax Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semax80714-61-0Amyloid-ββ-amyloid peptideAβAbetaIschemiaBDNFastrocytesnootropicneuroprotectiveischemia? modelAD modelneuronsInhibitorinhibitorinhibit

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