2. PROTAC Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. PROTACs Anaplastic lymphoma kinase (ALK) Akt ERK
  4. WZH-17-002

WZH-17-002 is a WZH-15-125-based ALK PROTAC degrader with a DC50 of 25 nM. WZH-17-002 enhances activities against Lorlatinib (HY-12215)-resistant ALK compound mutations. WZH-17-002 significantly reduces drug resistance in ALK-fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196 M xenograft mice model. Pink: ALK ligand (HY-174314); Blue: CRBN ligase ligand (HY-14658); Black: linker (HY-174316)

For research use only. We do not sell to patients.

WZH-17-002 Chemical Structure

WZH-17-002 Chemical Structure

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WZH-17-002 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

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Description

WZH-17-002 is a WZH-15-125-based ALK PROTAC degrader with a DC50 of 25 nM. WZH-17-002 enhances activities against Lorlatinib (HY-12215)-resistant ALK compound mutations. WZH-17-002 significantly reduces drug resistance in ALK-fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196 M xenograft mice model[1]. Pink: ALK ligand (HY-174314); Blue: CRBN ligase ligand (HY-14658); Black: linker (HY-174316)

Molecular Weight

1044.97

Formula

C47H54BrN11O10S
SMILES

O=C(N(CC1)CCN1C(CC2)CCN2C(C(CC)=C3)=CC(OC)=C3NC(N=C4NC5=CC=C6OCCOC6=C5N(S(C)(=O)=O)C)=NC=C4Br)CNC7=C8C(N(C9CCC(NC9=O)=O)C(C8=CC=C7)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WZH-17-002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WZH-17-002PROTACsAnaplastic lymphoma kinase (ALK)AktERKAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246PKBProtein kinase BExtracellular signal regulated kinasesPROTACDegradationALKAnticancerNon-small cell lung cancerNSCLCDFCI076 cellsH2228 cellsEML4-ALK G1202R/L1196 M xenograft mice modelInhibitorinhibitorinhibit

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WZH-17-002
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HY-174315
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