2. PROTAC Protein Tyrosine Kinase/RTK
  3. Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)
  4. WZH-15-125

WZH-15-125 is a potent ALK inhibitor. WZH-15-125 can effectively overcome drug resistance, especially compound ALK mutations. WZH-15-125 has an IC50 of 101.7 nM for the highly refractory G1202R/L1196M mutation that is resistant to Lorlatinib (HY-12215). WZH-15-125 can be used as a PROTAC target protein ligand to synthesize PROTAC WZH-17-002 (HY-174315). WZH-15-125 can be used in the research of non-small cell lung cancer.

For research use only. We do not sell to patients.

WZH-15-125 Chemical Structure

WZH-15-125 Chemical Structure

CAS No. : 2845188-22-7

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WZH-15-125 Related Antibodies

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Description

WZH-15-125 is a potent ALK inhibitor. WZH-15-125 can effectively overcome drug resistance, especially compound ALK mutations. WZH-15-125 has an IC50 of 101.7 nM for the highly refractory G1202R/L1196M mutation that is resistant to Lorlatinib (HY-12215). WZH-15-125 can be used as a PROTAC target protein ligand to synthesize PROTAC WZH-17-002 (HY-174315). WZH-15-125 can be used in the research of non-small cell lung cancer[1].

Molecular Weight

745.73

Formula

C33H45BrN8O5S
CAS No.
SMILES

BrC1=CN=C(N=C1NC2=CC=C3OCCOC3=C2N(S(C)(=O)=O)C)NC4=C(OC)C=C(C(CC)=C4)N5CCC(CC5)N6CCN(CC6)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WZH-15-125 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WZH-15-1252845188-22-7Ligands for Target Protein for PROTACAnaplastic lymphoma kinase (ALK)Target Protein-binding MoietyAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Ba/F3DFCI076H3122H2228PC9A549H460H157H292BEAS-2BMRC-5Inhibitorinhibitorinhibit

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WZH-15-125
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HY-174314
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