C-Reactive Protein (CRP) (174-185) 

C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of caspase-3/9 through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma^[1][5].

C-Reactive Protein (CRP) (0-25 μg/mL; 24 h) promotes monocyte migration by stimulating 3T3-L1 adipocytes to produce CXCL7^[3].
C-Reactive Protein (CRP) can impair G1/S-dependent regeneration of renal tubular epithelial cells^[4].
C-Reactive Protein (CRP) (10 μg/mL, 4 days) can enhance TSCC cell viability and increase cell resistance to DDP^[5].
C-Reactive Protein (CRP) is a highly structurally conserved major acute phase plasma protein in humans^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-Reactive Protein (CRP) (25 μg; once daily; 7 days; i.v.) can protect mice from pneumococcal infection by activating complement^[1].
C-Reactive Protein (CRP) (20 mg/kg; once daily; 3 days; i.p.) can induce superoxide anion release and tissue factor activity in rat macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1276.48

C₆₂H₉₃N₁₃O₁₆

147516-85-6

Solid

White to off-white

Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu

IYLGGPFSPNVL

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Singh SK, et al. Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection. Front Immunol. 2020 Aug 13;11:1812.  [Content Brief]

  [2]. Devaraj S, et al. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis. 2009 Mar;203(1):67-74.  [Content Brief]

  [3]. Chen JY, et al. C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia. J Transl Med. 2020 Feb 11;18(1):68.  [Content Brief]

  [4]. Tang Y, et al. C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration. Clin Sci (Lond). 2014 May;126(9):645-59.  [Content Brief]

  [5]. Yan X, et al. C-reactive protein promotes tongue squamous cell carcinoma chemoresistance by inhibiting the activation of caspase-3/9 via the CD64/AKT/mTOR pathway. Hum Cell. 2021 Sep;34(5):1424-1433.  [Content Brief]

  [6]. Ansar W, et al. C-reactive protein and the biology of disease. Immunol Res. 2013 May;56(1):131-42.  [Content Brief]