2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Anti-Mouse CD45RB Antibody (MB23G2)

Anti-Mouse CD45RB Antibody (MB23G2) 

Cat. No.: HY-P990267
Technical Support

Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection.

For research use only. We do not sell to patients.

Anti-Mouse CD45RB Antibody (MB23G2)

Anti-Mouse CD45RB Antibody (MB23G2) Chemical Structure

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Anti-Mouse CD45RB Antibody (MB23G2) Related Antibodies

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Description

Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD45RB Antibody (MB23G2) Related Antibodies
In Vivo

Anti-Mouse CD45RB Antibody (MB23G2) (100 μg, i.v., at days -1, 0, and 5) shows normoglycemic and prolongs survival in streptozotocin (HY-13753)-induced diabetic mice with islet grafts[1].
Anti-Mouse CD45RB Antibody (MB23G2) (200 μg, i.p., 1 day prior to infection and thereafter every 3 days) delays viral clearance in Mem71 (H3N1) virus-infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753)-induced diabetic mice with Islet grafts[1]
Dosage: 100 μg
Administration: Intravenously injection, at days -1, 0, and 5
Result: Became normoglycemic within 3 days and prolonged survival.
Reduced IL-2, IFN-α,and IL-4 mRNA amounts.
Decreased white blood cell counts on day 3 and 7.
Reduced the CD45RBbright population for a week, but the population had already partially returned 5 days after the last injection.
Animal Model: Mem71 (H3N1) virus-infected mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, 1 day prior to infection and thereafter every 3 days
Result: Showed delayed viral clearance.
Showed fewer T cells were present in both MLN and lung.
Reduced total influenza-specific CD8+ T cells.
Delayed the humoral response.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD45RB Antibody (MB23G2)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD45RB Antibody (MB23G2) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD45RB Antibody (MB23G2)PhosphataseCD45CD45RBDiabetesMem71 (H3N1)Islet graftsInhibitorinhibitorinhibit

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